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merck millipore,默克密理博,MABF579,Anti-CD4 Antibody (human), APC-Cy7, clone RPA-T4
产品名称：Anti-CD4 Antibody (human), APC-Cy7, clone RPA-T4
产品型号：MABF579
This mouse monoclonal antibody Anti-CD4 (human), APC-Cy7, clone RPA-T4 validated for use in IP, IHC & Flow Cytometry for the detection of CD4.
merck millipore,默克密理博,MABF579,Anti-CD4 Antibody (human), APC-Cy7, clone RPA-T4
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H FC, IHC M APC-Cy7 Monoclonal Antibody 描述 产品目录编号 MABF579 描述 Anti-CD4 Antibody (human), APC-Cy7, clone RPA-T4 Alternate Names - CD antigen CD4
- T-cell surface glycoprotein CD4
- T-cell surface antigen T4/Leu-3
背景信息 The RPA-T4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The RPA-T4 antibody is widely used as a phenotypic marker for human CD4 expression, and is cross-reactive with Chimpanzee CD4. This antibody recognizes a different epitope, and thus does not block binding of, the alternative Anti-Human CD4 antibody clone OKT4 (Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. 76:4061-4065). 产品信息 格式 APC-Cy7 演示 Purified Mouse Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide. 应用 应用 This mouse monoclonal antibody Anti-CD4 (human), APC-Cy7, clone RPA-T4 validated for use in IP, IHC & Flow Cytometry for the detection of CD4. 主要应用 - Flow Cytometry
- Immunohistochemistry
生物信息 免疫原品种 Immunogen information for this antibody is proprietary information. 克隆 RPA-T4 浓缩 5 μL (0.5 μg)/test 宿主 Mouse 同种型 IgG1κ 品种反应性 Human 抗体类型 Monoclonal Antibody 基因符号 - CD4
纯化方法 Size Exclusion Chromatography UniProt编号 - P01730
产品使用声明 质量保证 The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.
Flow Cytometry Analysis: 0.5 μg of this antibody detected CD4 in one million human peripheral blood lymphocytes.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze. 包装信息 数量 25 tests
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