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merck millipore,默克密理博,07-232,Anti-phospho-CENP-A (Ser7) Antibody
产品名称：Anti-phospho-CENP-A (Ser7) Antibody
产品型号：07-232
Detect phospho-CENP-A (Ser7) with Anti-phospho-CENP-A (Ser7) Antibody (Rabbit Polyclonal Antibody), that has been shown to work in WB.
merck millipore,默克密理博,07-232,Anti-phospho-CENP-A (Ser7) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 07-232 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-CENP-A (Ser7) Antibody 概述 CENP-A is a variant version of histone H3 found only at centromeres. It is phosphorylated at serine 7 during mitosis. 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Detect phospho-CENP-A (Ser7) with Anti-phospho-CENP-A (Ser7) Antibody (Rabbit Polyclonal Antibody), that has been shown to work in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 peptide contianing the sequence RRpSRK in which pS is phosphoserine corresponding to amino acid 7 of human CENP-A (centromere protein A) 宿主 Rabbit 特异性 phosphorylated CENP-A (Ser7) 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_001809
Entrez基因汇总 Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. 基因符号 - CENP-A
- CENPA
修改 - Phosphorylation
纯化方法 Protein A purfied UniProt编号 - P49450
UniProt汇总 FUNCTION: SwissProt: P49450 # Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.
SIZE: 140 amino acids; 15991 Da
SUBUNIT: Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, CENPA and H4 assembled in one CENPA-H4 heterotetramer and two H2A-H2B heterodimers. Nucleosomes containing CENPA also contain histone H2A variants such as macroH2A H2AFY and H2A.Z/H2AFZ. The CENPA-H4 heterotetramer is more compact and structurally more rigid than corresponding H3-H4 heterotetramers. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. Interacts directly with herpes virus HSV-1 ICP0 protein.
SUBCELLULAR LOCATION: Nucleus. Centromere. Kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres.
DOMAIN: SwissProt: P49450 The CATD (CENPA targeting domain) region is responsible for the more compact structure of nucleosomes containinf CENPA and is necessary and sufficient to mediate the localization into centromeres.
PTM: Ubiquitinated (Probable). Interaction with herpes virus HSV-1 ICP0 protein, leads to its degradation by the proteasome pathway. & Phosphorylation of Ser-7 by Aurora-A/STK6 and Aurora-B/STK12 during prophase is required for localization of Aurora-A/STK6 and Aurora-B/STK12 at inner centromere and is essential for kinetochore function. Initial phosphorylation during prophase is mediated by Aurora-A/STK6 and is maintained by Aurora-B/STK12.DISEASE:SwissProt: P49450 # Antibodies against CENPA are present in sera from patients with autoimmune diseases that developed autoantibodies against centrosomal proteins.
SIMILARITY: Belongs to the histone H3 family.产品使用声明 质量保证 routinely evaluated by immunoblot on acid extracted proteins from colcemid-arrested HeLa cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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