merck millipore,默克密理愽
  • merck millipore,默克密理博,MABF346,Anti-TGF-β1 (mouse) Antibody, PE, clone TW7-16B4

  • merck millipore,默克密理博,MABF346,Anti-TGF-β1 (mouse) Antibody, PE, clone TW7-16B4

    产品名称：Anti-TGF-β1 (mouse) Antibody, PE, clone TW7-16B4
    产品型号：MABF346
    Anti-TGF-β1 (mouse) Antibody, PE, clone TW7-16B4 is a highly specific mouse monoclonal antibody, that targets TGFβ & has been tested in Flow Cytometry, western blotting, IP & Neutralizing.

    merck millipore,默克密理博,MABF346,Anti-TGF-β1 (mouse) Antibody, PE, clone TW7-16B4

  • 产品介绍
  • merck millipore,默克密理博,MABF346,Anti-TGF-β1 (mouse) Antibody, PE, clone TW7-16B4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MWB, FCMPEMonoclonal Antibody
    描述
    产品目录编号 MABF346
    描述 Anti-TGF-β1 (mouse) Antibody, PE, clone TW7-16B4
    Alternate Names
    • TGFB
    • Transforming growth factor beta-1
    • TGF-beta-1
    • Latency-associated peptide
    • LAP
    • TGFB1
    背景信息 LAP, also known as TGF-beta1 or TGFB1, belongs to the TGF-beta family. TGFB1 is a multifunctional protein that controls proliferation, differentiation and other functions in various cell types. TGFB1 is synthesized by many cells that have specific receptors for it. It positively and negatively regulates many other growth factors. TGF-β1 plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. The 'straitjacket' and 'arm' domains encircle the growth factor monomers and are fastened together by strong bonding between Lys-56 and Tyr-103/Tyr-104. Activation of TGF-β1 requires the binding of integrin alpha-V to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-beta binding proteins. The physical force unfastens the straitjacket and releases the active growth factor dimer.
    产品信息
    格式 PE
    演示 Purified mouse conjugate antibody in buffer containing PBS (pH 7.2) with up to 0.1% sodium azide.
    应用
    应用 Anti-TGF-β1 (mouse) Antibody, PE, clone TW7-16B4 is a highly specific mouse monoclonal antibody, that targets TGFβ & has been tested in Flow Cytometry, western blotting, IP & Neutralizing.
    主要应用
    • Western Blotting
    • Flow Cytometry
    应用说明 Western Blotting Analysis: A representative lot detected human TGF-β1 in Western Blotting. (Oida T, et al. 2010.)

    Immunoprecipitation Analysis: A representative lot detected human TGF-β1 in Immunoprecipitation. (Oida T, et al. 2010.)

    Neutralization Assay Analysis: A representative lot detected human TGF-β1 in Neutralization Assay. (Oida T, et al. 2011.)
    生物信息
    免疫原品种 Mouse Tgfb1-transduced P3U1 cells
    克隆 TW7-16B4
    宿主 Mouse
    特异性 This antibody recognizes recombinant LAP, latent TGF-β, and pro-TGF-β.
    同种型 IgG1κ
    品种反应性 Mouse
    抗体类型 Monoclonal Antibody
    基因符号
    • TGFB
    • TGFB1
    纯化方法 Affinity
    UniProt编号
    • P04202
    产品使用声明
    质量保证 The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

    Flow Cytometry Analysis: 0.5 μg of this antibody detected TGF-β1 in one million C57BL/6 mouse splenocytes.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABF346,Anti-TGF-β1 (mouse) Antibody, PE, clone TW7-16B4

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