merck millipore,默克密理愽
  • merck millipore,默克密理博,06-1331,Anti-IL-23R Antibody, cytoplasmic

  • merck millipore,默克密理博,06-1331,Anti-IL-23R Antibody, cytoplasmic

    产品名称：Anti-IL-23R Antibody, cytoplasmic
    产品型号：06-1331
    Anti-IL-23R Antibody, cytoplasmic detects level of IL-23R & has been published & validated for use in WB, IH, ELISA, FC.

    merck millipore,默克密理博,06-1331,Anti-IL-23R Antibody, cytoplasmic

  • 产品介绍
  • merck millipore,默克密理博,06-1331,Anti-IL-23R Antibody, cytoplasmic

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HFC, WB, IHC, ELISARbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 06-1331
    描述 Anti-IL-23R Antibody, cytoplasmic
    Alternate Names
    • interleukin 23 receptor
    背景信息 Interleukin 23 receptor (IL-23R) is a type I cytokine receptor that is a subunit of the receptor for IL23A/IL23. IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. IL-23R associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3.
    产品信息
    格式 Affinity Purified
    控制
    • Jurkat cell lysate
    演示 Purified rabbit polyclonal in PBS with 0.05% sodium azide.
    应用
    应用 Anti-IL-23R Antibody, cytoplasmic detects level of IL-23R & has been published & validated for use in WB, IH, ELISA, FC.
    主要应用
    • Flow Cytometry
    • Western Blotting
    • Immunohistochemistry
    • ELISA
    应用说明 Immunohistochemistry Analysis: A 1:100 dilution from a previous lot detected IL-23R in mouse spleen tissue.

    Flow Cytometry Analysis: 2-10 µg from a previous lot detected IL-23R in human PBMCs. Does not work in mouse for flow cytometry.

    ELISA: A previous lot of this antibody was tested on ELISA by an independent laboratory.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human IL-23R at and around the cytoplasmic domain.
    表位 Cytoplasmic Domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes the cytoplasmic domain of IL-23R.
    May detect other isoforms of IL-23R (see molecular weight).
    品种反应性 MouseHuman
    Species Reactivity Note Proven to react with human and mouse.
    Does not work for mouse in flow cytometry.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_653302
    Entrez基因汇总 The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq]
    基因符号
    • IL-23R
    • il23r
    • IBD17
    纯化方法 Affinity Purfied
    UniProt编号
    • Q5VWK5
    UniProt汇总 FUNCTION: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

    SUBUNIT STRUCTURE: Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3.

    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.

    TISSUE SPECIFICITY: Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.

    PTM: Phosphorylated in response to IL23.

    INVOLVEMENT IN DISEASE: Genetic variation in IL23R is associated with inflammatory bowel disease type 17 (IBD17) [MIM:612261]. Inflammatory bowel disease (IBD) is a form of remitting Crohn disease (CD). CD may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. Bowel inflammation is transmural and discontinuous. CD is commonly classified as an autoimmune disease.

    Genetic variation in IL23R is associated with susceptibility to ulcerative colitis [MIM:191390]. It is a chronic inflammatory bowel disease. In ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers. Ulcerative colitis is commonly classified as autoimmune disease.

    Genetic variation in IL23R is associated with susceptibility to psoriasis [MIM:177900]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows and knees, and may be associated with severe arthritis. The lesions are caused by hyperproliferative keratinocytes and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age.

    SEQUENCE SIMILARITIES: Belongs to the type I cytokine receptor family. Type 2 subfamily.

    Contains 2 fibronectin type-III domains.
    产品使用声明
    质量保证 Evaluated by Western Blot in Jurkat cell lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected IL-23R on 10 µg of Jurkat cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,06-1331,Anti-IL-23R Antibody, cytoplasmic

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