merck millipore,默克密理愽
  • merck millipore,默克密理博,MABF343,Anti-CD126 (IL-6Rα) (human) Antibody, PE, clone UV4

  • merck millipore,默克密理博,MABF343,Anti-CD126 (IL-6Rα) (human) Antibody, PE, clone UV4

    产品名称：Anti-CD126 (IL-6Rα) (human) Antibody, PE, clone UV4
    产品型号：MABF343
    Detect IL-6 Receptor using this mouse monoclonal antibody, Anti-CD126 (IL-6Rα) (human) Antibody, PE & clone UV4 validated for use in Flow Cytometry.

    merck millipore,默克密理博,MABF343,Anti-CD126 (IL-6Rα) (human) Antibody, PE, clone UV4

  • 产品介绍
  • merck millipore,默克密理博,MABF343,Anti-CD126 (IL-6Rα) (human) Antibody, PE, clone UV4

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMPEMonoclonal Antibody
    描述
    产品目录编号 MABF343
    描述 Anti-CD126 (IL-6Rα) (human) Antibody, PE, clone UV4
    Alternate Names
    • CD126
    • Interleukin-6 receptor subunit alpha
    • IL-6 receptor subunit alpha
    • IL-6R subunit alpha
    • IL-6R-alpha
    • IL-6RA
    • IL-6R 1
    • Membrane glycoprotein 80
    • gp80
    背景信息 CD126, also known as Interleukin-6 (IL-6), is a pro-inflammatory cytokine that seems to be involved in the late stages of CTL generation. Other biological functions also include amplification and the inflammatory response. Combination therapies including IL-6 have been shown to have positive effects on specific malignant tumor types. The accumulation of IL-6 in the CNS is usually detrimental and can contribute to pathology of CNS diseases. IL-6 signaling is negatively regulated by TGF-beta, which down regulates STAT1, STAT3 and ICAM-1 expression. The interleukin-6 receptor (IL-6R) is thought to be made up of two subunits: IL-6R-alpha and gp130. IL-6R-alpha is ligand specific while signal transduction is regulated by gp130. IL-6R is commonly membrane bound but can also be found in a soluble form. It has been found to be inactivated by Porphyromonas gingivalis during infection, most possibly by damaging or inactivating the gp130 subunit of the receptor. IL-6R expression has been linked to aggressiveness of papillary thyroid cancers and medullary thyroid cancers and has also been linked to certain osteoarticular diseases. Recent data has found an association between a certain IL-6R polymorphism and susceptibility to respiratory infections. IL-6 expression has been linked to inflammatory bowel disease (IBD) and is also the primary clinical target for IBD. Clinical use of an antibody for the IL-6 receptor (IL-6R) has been promising in treating rheumatoid arthritis, systemic juvenile idiopathic arthritis and Castleman’s disease.
    产品信息
    格式 PE
    演示 Purified mouse conjugate antibody in buffer containing PBS (pH 7.2) with up to 0.1% sodium azide and 0.2% (w/v) BSA.
    应用
    应用 Detect IL-6 Receptor using this mouse monoclonal antibody, Anti-CD126 (IL-6Rα) (human) Antibody, PE & clone UV4 validated for use in Flow Cytometry.
    主要应用
    • Flow Cytometry
    生物信息
    免疫原品种 Human myeloma cell line U266
    克隆 UV4
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    基因符号
    • IL6R
    纯化方法 Affinity
    UniProt编号
    • P08887
    产品使用声明
    质量保证 The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

    Flow Cytometry Analysis: 5 μL of this antibody detected CD126 (IL-6Rα) in one million human blood lymphocytes.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
    包装信息
    数量 100 tests

    merck millipore,默克密理博,MABF343,Anti-CD126 (IL-6Rα) (human) Antibody, PE, clone UV4

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