merck millipore,默克密理愽
  • merck millipore,默克密理博,FCMAB252F,Milli-Mark™ Anti-GAPDH-FITC Antibody, clone 6C5

  • merck millipore,默克密理博,FCMAB252F,Milli-Mark™ Anti-GAPDH-FITC Antibody, clone 6C5

    产品名称：Milli-Mark™ Anti-GAPDH-FITC Antibody, clone 6C5
    产品型号：FCMAB252F
    Milli-Mark Anti-GAPDH-FITC Antibody, clone 6C5 is a purified monoclonal antibody labeled with Fluorescein isothiocyanate (FITC). This well characterized mAb specifically detects Glyceraldehyde-3-Pho More>>

    merck millipore,默克密理博,FCMAB252F,Milli-Mark™ Anti-GAPDH-FITC Antibody, clone 6C5

  • 产品介绍
  • merck millipore,默克密理博,FCMAB252F,Milli-Mark™ Anti-GAPDH-FITC Antibody, clone 6C5

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMFITCMonoclonal Antibody
    描述
    产品目录编号 FCMAB252F
    商名
    • Milli-Mark
    描述 Milli-Mark™ Anti-GAPDH-FITC Antibody, clone 6C5
    Alternate Names
    • EC 1.2.1.12
    • glyceraldehyde 3-phosphate dehydrogenase
    • aging-associated gene 9 protein
    • glyceraldehyde-3-phosphate dehydrogenase, GAPDH
    • G3PDH
    • GAPD
    • OK/SW-cl.12
    • MGC88685
    • G3PD
    背景信息 Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is an ubiquitous glycolytic enzyme present in reasonably high levels in almost all tissues. As a 'house-keeping' enzyme, it catalyzes the synthesis of 1,3-biphosphoglycerate, a "high energy" intermediate used for the synthesis of ATP. Besides its cytoplasmic action in metabolism it is also involved in the initial stages of apoptosis or oxidative stress response where GAPDH is translocated to the nucleus. Such actions may reflect the role of GAPDH in DNA repair or as one nuclear carrier for apoptotic molecules. GAPDH has also been found to bind specifically to proteins implicated in the pathogenesis of a variety of neurodegenerative disorders including the beta-amyloid precursor protein and the huntingtin protein where decreased function of GAPDH is associated with Alzheimer's and Huntington's disease fibroblasts. GAPDH has also been identified as a potential target for nitric oxide (NO)-mediated cellular toxicity. The complete and functional enzyme is a tetramer with each of four identical subunits occupying the vertex of a tetrahedron. Binding domains also include one principally interacting with NAD+ and another interacting with glyceraldehyde 3-phosphate (GAP).
    产品信息
    格式 FITC
    控制
    • A431 cells
    演示 Purified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    应用 Milli-Mark Anti-GAPDH-FITC Antibody, clone 6C5 is a purified monoclonal antibody labeled with Fluorescein isothiocyanate (FITC). This well characterized mAb specifically detects Glyceraldehyde-3-Phosphate Dehydrogenase and is validated for use in Flow Cytometry.
    主要应用
    • Flow Cytometry
    生物信息
    免疫原品种 Glyceraldehyde-3-phosphate dehydrogenase purified from rabbit muscle
    克隆 6C5
    宿主 Mouse
    特异性 Antibody recognizes Human Glyceraldehyde-3-Phosphate Dehydrogenase.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Tested and passed on Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_002037
    Entrez基因汇总 Glyceraldehyde-3-phosphate dehydrogenase catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. A GAPD pseudogene has been mapped to Xp21-p11 and 15 GAPD-like loci have been identified.
    基因符号
    • G3PD
    • GAPDH
    • G3PDH
    • GAPD
    纯化方法 Protein A Purified
    UniProt编号
    • P04406
    UniProt汇总 FUNCTION: SwissProt: P04406 # Independent of its glycolytic activity it is also involved in membrane trafficking in the early secretory pathway.

    SIZE: 335 amino acids; 36053 Da

    SUBUNIT: Homotetramer. Binds PRKCI.

    SUBCELLULAR LOCATION: Cytoplasm. Note=Postnuclear and Perinuclear regions. Membrane.

    SIMILARITY: SwissProt: P04406 ## Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
    产品使用声明
    质量保证 Evaluated by flow cytometry using A431 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.
    包装信息
    数量 100 tests

    merck millipore,默克密理博,FCMAB252F,Milli-Mark™ Anti-GAPDH-FITC Antibody, clone 6C5

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