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品种反应性 主要应用 宿主 格式 抗体类型 M WB, FC M Purified Monoclonal Antibody 描述 产品目录编号 04-151 描述 Anti-IFNAR-1 Antibody, clone MARI-5A3 Alternate Names - human interferon-alpha receptor (HuIFN-alpha-Rec)
- interferon (alpha, beta and omega) receptor 1
- beta-type antiviral protein
- alpha-type antiviral protein
- Type I interferon receptor 1
- Cytokine receptor family 2 member 1
- interferon-beta receptor 1
- Cytokine receptor class-II member 1
- IFN-alpha-REC
- interferon-alpha/beta receptor alpha chain
- IFN-alpha/beta receptor 1
- interferon alpha/beta receptor 1
背景信息 Interferon alpha/beta receptor 1 (IFNAR-1) is a single-pass type I membrane protein containing three fibronectin type-III domains and is a member of the type II cytokine receptor family. IFNAR-1 serves as an interferon receptor specific to interferons alpha and beta, a family of type I interferons critical to the promotion and the linking of adaptive and innate immune response. Type I interferons all bind to a heterodimeric receptor composed of two subunits, IFNAR-1 and IFNAR-2. The binding of the type I IFNs initializes tyrosine phosphorylation for several proteins such as; IFNR alpha/beta subunits, JAKs, STAT, and TYK2 proteins. 产品信息 格式 Purified 控制 - BALB/c splenocytes
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-IFNAR-1 Antibody, clone MARI-5A3 is an antibody against IFNAR-1 for use in FC, IP, WB, NEUT. 主要应用 - Western Blotting
- Flow Cytometry
应用说明 Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
Neutralizing Assay: A previous lot was used by an independent laboratory in neutralization studies. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)生物信息 免疫原品种 Recombinant protein corresponding to the extracellular domain of mouse IFNAR-1. 表位 Extracellular Domain 克隆 MARI-5A3 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes the extracellular domain of IFNAR-1. 同种型 IgG1κ 品种反应性 Mouse Species Reactivity Note Demonstrated to react with mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_034638
基因符号 - CRF2-1
- IFRC
- IFNAR1
- IFNBR
- IFN-R-1
- IFNAR
- AVP
纯化方法 Protein G Purified UniProt编号 - P33896
UniProt汇总 FUNCTION: Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SEQUENCE SIMILARITIES: Belongs to the type II cytokine receptor family.
Contains 3 fibronectin type-III domains.产品使用声明 质量保证 Evaluated by Flow Cytometry in BALB/c splenocytes.
Flow Cytometry Analysis: 5 µg of this antibody detected IFNAR-1 in BALB/c splenocytes.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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