merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3402B,Anti-GFAP Antibody, Biotin Conjugate,MAB3402B

  • merck millipore,默克密理博,MAB3402B,Anti-GFAP Antibody, Biotin Conjugate,MAB3402B

    产品名称：Anti-GFAP Antibody, Biotin Conjugate, MAB3402B
    产品型号：MAB3402B


    merck millipore,默克密理博,MAB3402B,Anti-GFAP Antibody, Biotin Conjugate,MAB3402B

  • 产品介绍
  • merck millipore,默克密理博,MAB3402B,Anti-GFAP Antibody, Biotin Conjugate,MAB3402B

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Ch, M, H, R, PoIHCMBiotinMonoclonal Antibody
    描述
    产品目录编号 MAB3402B
    描述 Anti-GFAP Antibody, Biotin Conjugate | MAB3402B
    Alternate Names
    • GFAP
    • Glial fibrillary acidic protein
    背景信息 Glial fibrillary acidic protein is a class-III intermediate filament. GFAP is the main constituent of intermediate filaments in astrocytes and serves as a cell specific marker that distinguishes differentiated astrocytes from other glial cells during the development of the central nervous system.
    产品信息
    格式 Biotin
    控制
    • Mouse adult brain tissue
    演示 Purified mouse monoclonal IgG1 conjugated to Biotin in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    主要应用
    • Immunohistochemistry
    生物信息
    免疫原品种 Purified glial filament protein (Debus, E., et al. (1983) Differentiation. 25:193-203.)
    宿主 Mouse
    同种型 IgG1
    品种反应性 ChickenMouseHumanRatPig
    Species Reactivity Note Demonstrated to react with Mouse. Predicted to react with Human, Rat, Porcine, and Chicken based on 100% sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_002046
    Entrez基因汇总 This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
    基因符号
    • GFAP
    纯化方法 Protein A Purified
    UniProt编号
    • P14136
    UniProt汇总 FUNCTION: GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

    SIZE: 432 amino acids; 49880 Da

    SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1.

    SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.

    DISEASE: Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.

    SIMILARITY: Belongs to the intermediate filament family.
    产品使用声明
    质量保证 Evaluated by Immunohistochemistry in mouse adult brain tissue.

    Immunohistochemistry Analysis: 1:100 dilution of this antibody detected GFAP in mouse adult brain tissue.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB3402B,Anti-GFAP Antibody, Biotin Conjugate,MAB3402B

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