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merck millipore,默克密理博,MABF297,Anti-RIG-I, clone 1C3 Antibody
产品名称：Anti-RIG-I, clone 1C3 Antibody
产品型号：MABF297
This Anti-RIG-I, clone 1C3 Antibody is validated for use in Western Blotting and Immunoprecipitation and Immunocytochemistry for the detection of RIG-I.
merck millipore,默克密理博,MABF297,Anti-RIG-I, clone 1C3 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABF297 描述 Anti-RIG-I, clone 1C3 Antibody Alternate Names - RIG-I
- Probable ATP-dependent RNA helicase DDX58
- DEAD box protein 58
- RIG-I-like receptor 1
- RLR-1
- Retinoic acid-inducible gene 1 protein
- RIG-1
- Retinoic acid-inducible gene I protein
背景信息 Retinoic acid-inducible gene 1 protein (RIG-1) is a cytoplasmic DExD/H box RNA helicase belonging to the helicase family and containing 2 CARD domains within the N-terminus, a repressor domain (RD), a helicase ATP-binding domain and a helicase C-terminal binding domain. RIG-1 is able to bind the 5’-triphosphate RNA of single or double-stranded viral RNA. After recognizing and binding viral RNA, RIG-1 protein initializes type I IFN production, and within fibroblasts and dendritic cells plays a central role in the regulation of type I IFN production in response to viral presence. There are four known isoforms resulting from alternative splice variants. 产品信息 格式 Purified 演示 Purified mouse monoclonal IgG1λ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-RIG-I, clone 1C3 Antibody is validated for use in Western Blotting and Immunoprecipitation and Immunocytochemistry for the detection of RIG-I. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunoprecipitation Analysis: A representative lot immunoprecipitated RIG-1 in A-549 infected with SeV cell lysate (Baum, A., et al. (2011). PNAS. 108(7):16303-16308).
Immunoprecipitation Analysis: A representative lot immunoprecipitated RIG-1 in A-459 lung carcinoma cell lysate (Nistal-Villan, E., et al. (2010). J. Biol. Chem. 285:20252-20261).
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected RIG-I in HeLa cells (Courtesy of Maite Sanchez).生物信息 免疫原品种 Recombinant protein corresponding to human RIG-I. 克隆 1C3 浓缩 Please refer to lot specific datasheet. 宿主 Mouse 同种型 IgG1λ 品种反应性 Human Species Reactivity Note Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_055129
基因符号 - DDX58
纯化方法 Protein G purified UniProt编号 - O95786
产品使用声明 质量保证 Evaluated by Western Blotting in A-549 infected with SeV cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected RIG-1 in 10 µg of A-549 infected with SeV cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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