merck millipore,默克密理博,04-445,Anti-Daxx Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-445,Anti-Daxx Antibody, rabbit monoclonal
产品名称：Anti-Daxx Antibody, rabbit monoclonal
产品型号：04-445
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-Daxx Antibody, Rabbit is validated for use More>>

merck millipore,默克密理博,04-445,Anti-Daxx Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-445,Anti-Daxx Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB, FC	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-445
品牌系列	Upstate
商名	Upstate
描述	Anti-Daxx Antibody, rabbit monoclonal

产品信息
格式	Purified
演示	In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-Daxx Antibody, Rabbit is validated for use in FC, IF, WB, IH(P) for the detection of Daxx.
主要应用	Western Blotting Flow Cytometry

生物信息
免疫原品种	KLH-conjugated synthetic peptide composed of residues of human Daxx.
宿主	Rabbit
特异性	Recognizes a region composed of residues of human Daxx.
同种型	IgG
品种反应性	Human
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_001350.3
基因符号	DAP6 DAXX MGC126246 Daxx BING2 hDaxx MGC126245 EAP1
UniProt编号	Q9UER7
UniProt汇总	FUNCTION: SwissProt: Q9UER7 # Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Down-regulates basal and activated transcription. Seems to act as a transcriptional co- repressor and inhibits PAX3 and ETS1 through direct protein- protein interaction. Modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. SIZE: 740 amino acids; 81373 Da SUBUNIT: Homomultimer. Binds to the TNFRSF6 death domain via its C-terminus and to PAX5. Binds to SLC2A4/GLUT4, MAP3K5, TGFBR2, phosphorylated dimeric HSPB1/HSP27, CENPC1, ETS1, sumoylated PML, UBE2I and MCRS1. Is part of a complex containing PAX5 and CREBBP. Interacts with HIPK2 and HIPK3 via its N-terminus. Interacts with HIPK1, which induces translocation from PML/POD/ND10 nuclear bodies to chromatin and enhances association with HDAC1 (By similarity). The non-phosphorylated form binds to PAX3, PAX7, DEK, HDAC1, HDAC2, HDAC3, acetylated histone H4 and histones H2A, H2B, H3 and H4. Interacts with SPOP. Part of a complex consisting of DAXX, CUL3 and SPOP. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli. Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres. Detected in cytoplasmic punctate structures. Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress.TISSUE SPECIFICITY: Ubiquitous. PTM: Sumoylated. & Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by HIPK1 upon glucose deprivation. & Polyubiquitinated; which is promoted by CUL3 and SPOP and results in proteasomal degradation. SIMILARITY: SwissProt: Q9UER7 ## Belongs to the DAXX family.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.