merck millipore,默克密理博,MABE370,Anti-Thymidylate Synthase-5FU complex Antibody, clone FTS

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	R	Purified	Monoclonal Antibody

描述
产品目录编号	MABE370
描述	Anti-Thymidylate Synthase-5FU complex Antibody, clone FTS
Alternate Names	Tsase Thymidylate synthase TS
背景信息	Thymidylate Synthase (TS), a cytosolic enzyme, is a dimer of two identical monomers of about 36kDa. The enzyme provides the sole intracellular de novo source of thymidylate and plays a crucial role in DNA replication and repair. TS catalyzes the methylation of deoxyuridine monophosphate (dump) and its conversion to deoxythymidine monophosphate (dTMP). Therefore, TS is primarily active in proliferating and metabolic active cells. TS is a central target of the widely used antineoplastic agent 5-Fluorouracil (5-FU) and thus also of the Xeloda, which is enzymatically activated to 5-FU. TS is inactivated by a covalent complex formation with 5-FdUMP and methylenetetrahydrofolate. Literature indicates that expression of TS is associated with response to 5-fluorouracil (5-FU) in human breast, colorectal, gastric, head, and neck carcinomas with low TS expression predicting better response to 5-FU and survival.

产品信息
格式	Purified
控制	5FU treated RKO cell lysate
演示	Purified rat monoclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Detect Thymidylate Synthase using this rat monoclonal antibody, Anti-Thymidylate Synthase-5FU complex Antibody & clone FTS validated for use in western blotting.
主要应用	Western Blotting

生物信息
免疫原品种	Corresponding to human Thymidylate Synthase-5FU complex.
克隆	FTS
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rat
特异性	This antibody demonstrates specificity against Thymidylate Synthase-5FU complex , and does not cross react with Thymidylate Synthase (Patel, K., et al. (2012). Oncotarget. 3(7):678-685).
品种反应性	Human
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_001062
基因符号	TS TYMS
纯化方法	Protein G purified
UniProt编号	P04818

产品使用声明
质量保证	Evaluated by Western Blotting in RKO cell lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected Thymidylate Synthase-5FU complex in 10 µg of RKO cell lysates treated with 5 FU, and demonstrated a loss of signal in untreated RKO cell lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MABE370,Anti-Thymidylate Synthase-5FU complex Antibody, clone FTS

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