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品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB15115 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-NARC-1 Antibody Alternate Names - Neural Apoptosis-Regulated Convertase 1, PCSK9
- Neural Apoptosis-Regulated Convertase 1
产品信息 格式 Serum 演示 Rabbit serum. 应用 应用 NARC-1 is an antibody targeting the NARC-1 protein, validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic peptide. 宿主 Rabbit 特异性 Neural apoptosis-regulated convertase 1 [NARC-1, Pcsk9]. By Western blot the antibody recognizes a doublet at ~76 kDa in mouse liver lysate. 品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_174936.2
Entrez基因汇总 This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). 基因符号 - HCHOLA3
- PCSK9
- NARC1
- NARC-1
- FH3
纯化方法 Serum UniProt编号 - Q8NBP7
UniProt汇总 FUNCTION: SwissProt: Q8NBP7 # May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.
COFACTOR: Calcium (Probable).
SIZE: 692 amino acids; 74372 Da
SUBUNIT: The precursor protein but not the mature protein may form multimers.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
PTM: The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.
DISEASE:SwissProt: Q8NBP7 # Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.
SIMILARITY: SwissProt: Q8NBP7 ## Belongs to the peptidase S8 family. & Contains 1 peptidase S8 domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20degC in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,AG952,Tau-381, recombinant human
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