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品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-611 品牌系列 Upstate
商名 - Upstate
描述 Anti-Peroxiredoxin 3 Antibody 产品信息 格式 Serum 演示 antiserum in 0.05% sodium azide before the addition of glycerol to 30% 应用 应用 Detect Peroxiredoxin 3 using this Anti-Peroxiredoxin 3 Antibody validated for use in WB & IC. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 Full-length human Peroxiredoxin recombinant protein tagged with hexahistidine 宿主 Rabbit 特异性 Peroxiredoxin 3 同种型 IgG 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006793 and others
Entrez基因汇总 This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene. 基因符号 - PRO1748
- PRDX3
- SP-22
- HBC189
- MGC104387
- MER5
- AOP-1
- MGC24293
- Peroxiredoxin-3
- AOP1
纯化方法 Serum UniProt编号 - P30048
UniProt汇总 FUNCTION: SwissProt: P30048 # Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical- generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.
SIZE: 256 amino acids; 27693 Da
SUBUNIT: Homodimer; disulfide-linked, upon oxidation (By similarity). Binds MAP3K13.
SUBCELLULAR LOCATION: Mitochondrion.
SIMILARITY: SwissProt: P30048 ## Belongs to the ahpC/TSA family.
MISCELLANEOUS: The active site is the redox-active Cys-108 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-229-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin. & Irreversibly inactivated by overoxidation of Cys- 108 (to Cys-SO(3)H) upon oxidative stress.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from Du145 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 50 µL
上一件merck millipore产品：merck millipore,默克密理博,MAB411,Anti-Interferon-α Antibody, clone ST10,29,225,254
下一件merck millipore产品：merck millipore,默克密理博,AB1892,Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, NT
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