merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE330,Anti-c-ErbB2/c-Neu Antibody, clone 3B5

  • merck millipore,默克密理博,MABE330,Anti-c-ErbB2/c-Neu Antibody, clone 3B5

    产品名称：Anti-c-ErbB2/c-Neu Antibody, clone 3B5
    产品型号：MABE330
    Anti-c-ErbB2/c-Neu Antibody, clone 3B5 is a Mouse Monoclonal Antibody for detection of c-ErbB2/c-Neu also known as MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2 or CD340, has been validated in W More>>

    merck millipore,默克密理博,MABE330,Anti-c-ErbB2/c-Neu Antibody, clone 3B5

  • 产品介绍
  • merck millipore,默克密理博,MABE330,Anti-c-ErbB2/c-Neu Antibody, clone 3B5

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE330
    Replaces 04-1127
    描述 Anti-c-ErbB2/c-Neu Antibody, clone 3B5
    Alternate Names
    • CD340
    • Receptor tyrosine-protein kinase erbB-2
    • Metastatic lymph node gene 19 protein
    • MLN 19
    • Proto-oncogene Neu
    • Proto-oncogene c-ErbB-2
    • Tyrosine kinase-type cell surface receptor HER2
    • p185erbB2
    背景信息 The ErbB2 (HER2, c-Neu, ErbB2, c-erbB2, or HER2/neu) protein is member of the human epidermal growth factor receptor (HER) family. It is a receptor tyrosine kinase containing an intracellular kinase domain and an extracellular ligand domain, although no endogenous ligand has yet been found. ErbB2 dimerizes with ErbB1, 3, and 4, and can activate different pathways including the PI3K, PLCγ, and MAPK pathways, depending on the ErbB receptor involved. Coupling with ErbB3 activates the PI3K pathway, whereas coupling with any of these three receptors can induce the MAPK pathway. ErbB2 signaling promotes cell proliferation and inhibits apoptosis. ErbB2 is overexpressed in various cancers and may play a role in the development and metastasis of gliomas, and ovarian, breast, lung, and gastric cancer.
    产品信息
    格式 Purified
    控制
    • SK-BR-3 cell lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-c-ErbB2/c-Neu Antibody, clone 3B5 is a Mouse Monoclonal Antibody for detection of c-ErbB2/c-Neu also known as MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2 or CD340, has been validated in WB & IHC.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected c-ErbB2/c-Neu in human breast cancer tissue.
    生物信息
    免疫原品种 Linear peptide corresponding human c-ErbB2/c-Neu.
    克隆 3B5
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001005862
    基因符号
    • NGL
    • ERBB2
    • HER2
    • MLN19
    • NEU
    纯化方法 Protein G purified
    UniProt编号
    • P04626
    产品使用声明
    质量保证 Evaluated by Western Blot in SK-BR-3 cell lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected c-ErbB2/c-Neu in 10 µg of SK-BR-3 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABE330,Anti-c-ErbB2/c-Neu Antibody, clone 3B5

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