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merck millipore,默克密理博,MABE232,Anti-IGF2BP2 Antibody, clone 5E10-3E1
产品名称：Anti-IGF2BP2 Antibody, clone 5E10-3E1
产品型号：MABE232
Use Anti-IGF2BP2 Antibody, clone 5E10-3E1 (mouse monoclonal antibody) validated in WB to detect IGF2BP2 also known as Insulin-like growth factor 2 mRNA-binding protein 2, IGF2 mRNA-binding protein 2, More>>
merck millipore,默克密理博,MABE232,Anti-IGF2BP2 Antibody, clone 5E10-3E1
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 MABE232 描述 Anti-IGF2BP2 Antibody, clone 5E10-3E1 Alternate Names - VICKZ family member 2
- Insulin-like growth factor 2 mRNA-binding protein 2
- IGF2 mRNA-binding protein 2
- IMP-2
- Hepatocellular carcinoma autoantigen p62
- IGF-II mRNA-binding protein 2
背景信息 Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) is a member of the IGF-II mRNA binding protein family that posttranscriptionally regulates IGF2 during developmental stages. IGF2 mRNA-binding protein family members (IGF2BP1, 2 and 3) bind UTR region of IGF2 transcripts and are implicated in the transport of RNA targets to enable protein synthesis at specific locations in the cytoplasm. Studies have indicated variations in the IGF2BP2 gene may affect fetal glucose metabolism and plays a role in type 2 diabetes. In addition to playing a role in glucose metabolism and dieabetes, the insulin-like growth factor (IGF) signaling axis plays an important role in cancer biology. Research has shown IGF2 to be emerging as an important gene for ovarian cancer. 产品信息 格式 Purified 控制 - HepG2 cell lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Use Anti-IGF2BP2 Antibody, clone 5E10-3E1 (mouse monoclonal antibody) validated in WB to detect IGF2BP2 also known as Insulin-like growth factor 2 mRNA-binding protein 2, IGF2 mRNA-binding protein 2, IMP-2, Hepatocellular carcinoma autoantigen p62. 主要应用 - Western Blotting
生物信息 免疫原品种 Histidine-tagged recombinant protein corresponding to human IGF2BP2. 克隆 5E10-3E1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001007226
Entrez基因汇总 This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. 基因符号 - VICKZ2
- IGF2BP2
- IMP2
纯化方法 Protein G purified UniProt编号 - Q9Y6M1
UniProt汇总 FUNCTION: Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May regulate translation of target mRNAs.
SUBUNIT STRUCTURE: Interacts with HNRPD and IGF2BP1.
SUBCELLULAR LOCATION: Cytoplasm. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa.
TISSUE SPECIFICITY: Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.
DOMAIN: The third and fourth KH domains are important for binding to the untranslated region (UTR) of target mRNA.
MISCELLANEOUS: Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma.
SEQUENCE SIMILARITIES: Belongs to the RRM IMP/VICKZ family.
Contains 4 KH domains.
Contains 2 RRM (RNA recognition motif) domains.
SEQUENCE CAUTION: The sequence AAH21290.1 differs from that shown. Reason: Erroneous initiation.产品使用声明 质量保证 Evaluated by Western Blot in HepG2 cell lysate.
Western Blot Analysis: A 1:20,000 dilution of this antibody detected IGF2BP2 on 10 µg of HepG2 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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