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merck millipore,默克密理博,MABE148,Anti-HMGB1 Antibody, clone HMG1-5H6
产品名称：Anti-HMGB1 Antibody, clone HMG1-5H6
产品型号：MABE148
Use Anti-HMGB1 Antibody, clone HMG1-5H6 (Hamster Monoclonal Antibody) validated in WB, IF, FC to detect HMGB1 also known as High-mobility group box 1.
merck millipore,默克密理博,MABE148,Anti-HMGB1 Antibody, clone HMG1-5H6
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M, H FC, WB Ht Purified Monoclonal Antibody 描述 产品目录编号 MABE148 描述 Anti-HMGB1 Antibody, clone HMG1-5H6 Alternate Names - high-mobility group box 1
- High mobility group protein 1
- Sulfoglucuronyl carbohydrate binding protein
- high mobility group box 1
- high-mobility group (nonhistone chromosomal) protein 1
背景信息 HMG-1 (High-Mobility-Group protein, amphoterin) is a highly conserved protein with more than 95% amino acid identity between rodent and human HMG-1. It is a prevalent non-histone chromatin component and a non-sequence specific DNA binding protein. HMG-1 consists of two homologous HMG boxes rich in basic amino acids and an acidic tail at the carboxy-terminus. HMG-1 is involved in the regulation of chromatin structure as well as being involved, either as positive or negative factors with various aspects of DNA replication, transcription, repair, and ligation. HMG-1, identified as a membrane associated protein termed “amphoterin,” mediates neurite outgrowth, tumor outgrowth, and metastasis. It participates in plasminogen activation and is recognized as a late mediator of endotoxin lethality in mice. 产品信息 格式 Purified 控制 - NIH/3T3 cell lysate
演示 Purified hamster monoclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Use Anti-HMGB1 Antibody, clone HMG1-5H6 (Hamster Monoclonal Antibody) validated in WB, IF, FC to detect HMGB1 also known as High-mobility group box 1. 主要应用 - Flow Cytometry
- Western Blotting
应用说明 Immunofluorescence Analysis: 10 µg/mL from a representative lot detected HMGB1 in NIH/3T3 cells. (Image courtesy of Dr. Hideo Yagita, Juntendo University School of Medicine.)
Flow Cytometry Analysis: A representative lot detected HMGB1 in RAW264.7 cells treated with Cytofix/Cytoperm. (Image courtesy of Dr. Hideo Yagita, Juntendo University School of Medicine.)生物信息 免疫原品种 Recombinant protein corresponding to mouse HMGB1. 克隆 HMG1-5H6 宿主 Hamster 品种反应性 RatMouseHuman Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_034569
基因符号 - SBP-1
- HMGB1
- HMG1
- Amphoterin
- HMG3
纯化方法 Protein G UniProt编号 - P09429
UniProt汇总 DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. 产品使用声明 质量保证 Evaluated by Western Blot in NIH/3T3 cell lysate.
Western Blot Analysis: 1:500 dilution of this antibody detected HMGB1 on 10 µg of NIH/3T3 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,203351,Blasticidin S, Hydrochloride, Streptomyces sp., Sterile-Filtered Aqueous Solution, Cell Culture-Tested - CAS 589205 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,05-1470,Anti-Raptor Antibody, clone 1H6.2
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