- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,MAB10054,Anti-Cytochrome P450 3A4 Antibody, clone F24 P2 B10
产品名称：Anti-Cytochrome P450 3A4 Antibody, clone F24 P2 B10
产品型号：MAB10054
This Anti-Cytochrome P450 3A4 Antibody, clone F24 P2 B10 is validated for use in WB for the detection of Cytochrome P450 3A4.
merck millipore,默克密理博,MAB10054,Anti-Cytochrome P450 3A4 Antibody, clone F24 P2 B10
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB10054 描述 Anti-Cytochrome P450 3A4 Antibody, clone F24 P2 B10 Alternate Names - glucocorticoid-inducible P450
- Albendazole monooxygenase
- Albendazole sulfoxidase
- Cytochrome P450 3A3
- Nifedipine oxidase
- P450-III, steroid inducible
- Quinine 3-monooxygenase
- Taurochenodeoxycholate 6-alpha-hydroxylase
- cytochrome P450, family 3, subfamily A, polypeptide 4
- cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3
- cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
背景信息 Cytochromes P450 are a superfamily of isoenzymes present in a wide variety of life-forms including animals, plants, fungi and microorganisms. The widespread interest in P450 is justified by the enormous range of physiological processes which involve enzymes from this family. These include, but are not limited to, steroid metabolism, drug deactivation, procarcinogen activation and xenobiotic detoxification. 产品信息 格式 Purified 控制 - Human liver tissue lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 This Anti-Cytochrome P450 3A4 Antibody, clone F24 P2 B10 is validated for use in WB for the detection of Cytochrome P450 3A4. 主要应用 - Western Blotting
生物信息 免疫原品种 Ovalbumin-conjugated linear peptide corresponding to human Cytochrome P450 3A4. 表位 Unknown 克隆 F24 P2 B10 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes Cytochrome P450 3A4. 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_059488
Entrez基因汇总 This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq]. 基因符号 - P450PCN1
- CP33
- CP34
- CYP3A
- CYP3A3
- CYPIIIA3
- CYPIIIA4
- HLP
- HLp
- NF-25
- P450-PCN1
- P450C3
纯化方法 Protein G purfied UniProt编号 - P08684
UniProt汇总 FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide.
CATALYTIC ACTIVITY: Quinine + NADPH + O2 = 3-hydroxyquinine + NADP+ + H2O.
Taurochenodeoxycholate + NADPH + O2 = taurohyocholate + NADP+ + H2O.
Lithocholate + NADPH + O2 = hyodeoxycholate + NADP+ + H2O.
Albendazole + NADPH + O2 = albendazole S-oxide + NADP+ + H2O.
COFACTOR: Heme group.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
TISSUE SPECIFICTY: Expressed in prostate and liver.
INDUCTION: By glucocorticoids. Also induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
SEQUENCE SIMILARITIES: Belongs to the cytochrome P450 family.产品使用声明 质量保证 Evaluated by Western Blot in human liver tissue lysate.
Western Blot Analysis: 2 µg/mL of this antibody detected Cytochrome P450 3A4 on 10 µg of human liver tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,324707,ELUGENT™ Detergent, 50% Solution - CAS 132778-08-6 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,ABN160,Anti-ARMS2 Antibody
相关产品
merck millipore,默克密理博,MAB3826,Anti-Mucin 5B Antibody, clone 19.4E
merck millipore,默克密理博,MABE148,Anti-HMGB1 Antibody, clone HMG1-5H6
merck millipore,默克密理博,05-1470,Anti-Raptor Antibody, clone 1H6.2
merck millipore,默克密理博,324707,ELUGENT™ Detergent, 50% Solution - CAS 132778-08-6 - Calbiochem
merck millipore,默克密理博,ABN160,Anti-ARMS2 Antibody
merck millipore,默克密理博,AP503H,Goat Anti-Chicken IgG (H+L) Antibody, PE conjugate
merck millipore,默克密理博,FC010-5MG,Human Plasma Fibronectin Purified Protein
merck millipore,默克密理博,05-338,Anti-Fas Antibody (human, neutralizing), clone ZB4
merck millipore,默克密理博,GF430,HumanKine IL-6, Human Recombinant Xeno-Free