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merck millipore,默克密理博,MAB3318,Anti-TIMP-3 Antibody, a.a. 170-188, clone 136-13H4
产品名称：Anti-TIMP-3 Antibody, a.a. 170-188, clone 136-13H4
产品型号：MAB3318
Anti-TIMP-3 Antibody, a.a. 170-188, clone 136-13H4 is an antibody against TIMP-3 for use in IH(P) & WB.
merck millipore,默克密理博,MAB3318,Anti-TIMP-3 Antibody, a.a. 170-188, clone 136-13H4
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Rb, H WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB3318 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-TIMP-3 Antibody, a.a. 170-188, clone 136-13H4 Alternate Names - Tissue Inhibitor of Metalloproteinase-3
产品信息 格式 Purified 控制 - Breast carcinoma tissue
演示 Liquid in 0.1 M sodium phosphate buffer, pH 7.0 containing 2% protease free bovine Serum albumin. 应用 应用 Anti-TIMP-3 Antibody, a.a. 170-188, clone 136-13H4 is an antibody against TIMP-3 for use in IH(P) & WB. 主要应用 - Western Blotting
应用说明 Immunoblotting: 2 ug/mL
Immunohistochemistry (Paraffin):10ug/mL
Immunohistochemistry (Frozen): 2 ug/mL生物信息 免疫原品种 Oligopeptide of SWYRGWAPPDKSIINATDP (residue 170-188) on human tissue inhibitor of metalloproteinases-3. 表位 a.a. 170-188 克隆 136-13H4 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Specifically reacts with human TIMP-3. This is a purified mouse monoclonal antibody to an oligopeptide of SWYRGWAPPDKSIINATDP (residue 170-188) on human tissue inhibitor of metalloproteinases-3 (human TIMP-3).
MAB3318 cross-reacts with rabbit TIMP-3, but does not react with human TIMP-1 and human TIMP-2.同种型 IgG1κ 品种反应性 RabbitHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000362.4
Entrez基因汇总 This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. 基因符号 - SFD
- TIMP3
- HSMRK222
- K222
- K222TA2
- TIMP-3
纯化方法 Protein A purfied UniProt编号 - P35625
UniProt汇总 FUNCTION: SwissProt: P35625 # Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. May form part of a tissue- specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
SIZE: 211 amino acids; 24145 Da
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
DISEASE: SwissProt: P35625 # Defects in TIMP3 are the cause of Sorsby fundus dystrophy (SFD) [MIM:136900]. SFD is a rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years.
SIMILARITY: SwissProt: P35625 ## Belongs to the protease inhibitor I35 (TIMP) family. & Contains 1 NTR domain.产品使用声明 销售限制 This product is not available for sale in Japan. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
- Manufactured by Daiichi Fine Chemical Co., Ltd
储存和货运信息 存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 100 µg
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