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  • merck millipore,默克密理博,MABE120,Anti-hSNF2H Antibody, clone 8F9.1

  • merck millipore,默克密理博,MABE120,Anti-hSNF2H Antibody, clone 8F9.1

    产品名称：Anti-hSNF2H Antibody, clone 8F9.1
    产品型号：MABE120
    Use Anti-hSNF2H Antibody, clone 8F9.1 (mouse monoclonal antibody) validated in WB, ICC to detect hSNF2H also known as SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily More>>

    merck millipore,默克密理博,MABE120,Anti-hSNF2H Antibody, clone 8F9.1

  • 产品介绍
  • merck millipore,默克密理博,MABE120,Anti-hSNF2H Antibody, clone 8F9.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE120
    描述 Anti-hSNF2H Antibody, clone 8F9.1
    Alternate Names
    • Sucrose nonfermenting protein 2 homolog
    • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
    • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5
    背景信息 The hSNF2H protein, a product of the SMARCA5 gene, is a member of the Imitation Switch (ISWI) family. This chromatin remodeling protein has ATP-dependent helicase activity and is implicated in the regulation of replication-associated nucleosome assembly as well as global chromatin structure. The hSNF2H protein has also been implicated in the transcriptional regulation of some genes. For example, studies suggest that hSNF2H is associated with activation and inactivation of cytokine genes and potentially the propagation and aggressiveness of some types of cancer.
    产品信息
    格式 Purified
    控制
    • HeLa cell lysate
    演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-hSNF2H Antibody, clone 8F9.1 (mouse monoclonal antibody) validated in WB, ICC to detect hSNF2H also known as SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: A 1:500 dilution of a representative lot of this antibody detected hSNF2H in HeLa and A431 cells.
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to human hSNF2H.
    克隆 8F9.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2bκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_003592
    Entrez基因汇总 Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. [provided by RefSeq].
    基因符号
    • WCRF135
    • SMARCA5
    • SNF2H
    纯化方法 Protein G
    UniProt编号
    • O60264
    UniProt汇总 FUNCTION: Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.

    SUBUNIT STRUCTURE: Catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. Each complex contains subunits which may regulate the specificity or catalytic activity of SMARCA5. ACF/WCRF contains BAZ1A; CHRAC contains BAZ1A, CHRAC1, and POLE3; RSF contains RSF1; WICH contains BAZ1B/WSTF. SMARCA5 is the catalytic subunit of the NoRC chromatin-remodeling complex, which also contains BAZ2A/TIP5. The BAZ2A/TIP5 subunit of NoRC also interacts with DNMT1, DNMT3B and HDAC1, which allows NoRC to actively suppress rDNA transcription by a combination of nucleosome remodeling, histone deacetylation, and DNA methylation. Catalytic subunit of SMARCA5/cohesin/NuRD complexes. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Interacts with MYO1C (By similarity).

    SUBCELLULAR LOCATION: Nucleus.

    TISSUE SPECIFICITY: Ubiquitously expressed.

    DEVELOPMENTAL STAGE: Overexpressed in CD34-positive erythrocyte progenitor cells in acute myeloid leukemia. Down-regulation correlates with hematologic remission following chemotherapy.

    SEQUENCE SIMILARITIES: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 2 SANT domains.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected hSNF2H on 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABE120,Anti-hSNF2H Antibody, clone 8F9.1

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