merck millipore,默克密理愽
  • merck millipore,默克密理博,MABD99,Anti-Nkx2.2 Antibody, clone 1C11

  • merck millipore,默克密理博,MABD99,Anti-Nkx2.2 Antibody, clone 1C11

    产品名称：Anti-Nkx2.2 Antibody, clone 1C11
    产品型号：MABD99
    Anti-Nkx2.2 Antibody, clone 1C11 is a highly specific mouse monoclonal antibody & that targets NKX2.2 & has been tested in western blotting.

    merck millipore,默克密理博,MABD99,Anti-Nkx2.2 Antibody, clone 1C11

  • 产品介绍
  • merck millipore,默克密理博,MABD99,Anti-Nkx2.2 Antibody, clone 1C11

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABD99
    描述 Anti-Nkx2.2 Antibody, clone 1C11
    Alternate Names
    • Homeobox protein NK-2 homolog B
    • Homeobox protein Nkx-2.2
    背景信息 Homeobox protein Nkx2.2 is a NK2 family transcription factor that contains a 60 AA (128 to 187) DNA binding homeobox. Nkx2.2 is part of a homeodomain protein combinatorial code that specifies progenitor cell identity and neuronal fate in the ventral neural tube. Nkx2-2 is required for the establishment of the dopaminergic progenitor domain in mammalian ventral midbrain and serotonergic (5-HT) neurons in the brainstem and ventral spinal cord. Nkx2.2 is selectively expressed in oligodendrocyte progenitors (OPC) that arise from glial precursors located in the ventral neural tube. Studies have shown Nkx2.2 is a key regulator of oligodendrocyte differentiation by regulating differentiation and/or maturation, but not the initial specification of oligodendrocyte progenitors.
    产品信息
    格式 Purified
    控制
    • Mouse E13-14 brain tissue lysate
    演示 Purified mouse monoclonal IgG2aκ in buffer containing PBS with 0.05% sodium azide.
    应用
    应用 Anti-Nkx2.2 Antibody, clone 1C11 is a highly specific mouse monoclonal antibody & that targets NKX2.2 & has been tested in western blotting.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Recombinant protein corresponding to human Nkx2.2.
    克隆 1C11
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2aκ
    品种反应性 Mouse
    Species Reactivity Note Demonstrated to react with Mouse.
    Predicted to react with Human based on immunogen design.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_002500
    Entrez基因汇总 The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008].
    基因符号
    • NKX2B
    • NKX2-2
    • NKX2.2
    纯化方法 Protein G Purified
    UniProt编号
    • O95096
    UniProt汇总 FUNCTION: Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity).

    SUBUNIT STRUCTURE: Interacts with OLIG2 (By similarity).

    SUBCELLULAR LOCATION: Nucleus (By similarity).

    DOMAIN: The homeodomain is essential for interaction with OLIG2 (By similarity).

    SEQUENCE SIMILARITIES: Belongs to the NK-2 homeobox family.

    Contains 1 homeobox DNA-binding domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in mouse E13-14 brain tissue lysate.

    Western Blot Analysis: 1 µg/mL of this antibody detected Nkx2.2 in 10 µg of mouse E13-14 brain tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABD99,Anti-Nkx2.2 Antibody, clone 1C11

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