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品种反应性 主要应用 宿主 格式 抗体类型 M, H IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB2988 Replaces 07-538 描述 Anti-LYVE1 Antibody Alternate Names - Cell surface retention sequence-binding protein 1
- Extracellular link domain-containing protein 1
- Hyaluronic acid receptor
- cell surface retention sequence binding protein-1
- extracellular link domain containing 1
- extracellular link domain-containing 1
- lymphatic vessel endothelial hyaluronan receptor 1
背景信息 LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE1 may function in lymphatic hyaluronan transport. Additionally, LYVE1 has a role in tumor metastasis. 产品信息 格式 Affinity Purified 控制 - Ovarian cancer tissue
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-LYVE1 Antibody is an antibody against LYVE1 for use in IH. 主要应用 - Immunohistochemistry
应用说明 Not recommended to work in western blot using mouse liver lysate. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to mouse LYVE1. 表位 Unknown 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes LYVE1. 同种型 IgG 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with human. Predicted to react with mouse based on 100% sequence homology. Rat (90% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_444477
Entrez基因汇总 This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. 基因符号 - XLKD1
- LYVE1
- CRSBP-1
- CRSBP1
- HARl
- LYVE-1
纯化方法 Affinity Purfied UniProt编号 - Q8BHC0
UniProt汇总 FUNCTION: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
SUBUNIT STRUCTURE: Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Note: Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.
PTM: O-glycosylated By similarity.
SEQUENCE SIMILARITIES: Contains 1 Link domain.产品使用声明 质量保证 Evaluated by Immunohistochemistry in ovarian cancer tissue.
Immunohistochemistry Analysis: 1:1,000 dilution of this antibody detected LYVE1 in ovarian cancer tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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