merck millipore,默克密理愽
  • merck millipore,默克密理博,MABD89,Anti-Podocalyxin-like protein I (Cytotoxic) Antibody, clone mAb 84

  • merck millipore,默克密理博,MABD89,Anti-Podocalyxin-like protein I (Cytotoxic) Antibody, clone mAb 84

    产品名称：Anti-Podocalyxin-like protein I (Cytotoxic) Antibody, clone mAb 84
    产品型号：MABD89
    Anti-Podocalyxin-like protein I (Cytotoxic) Antibody, clone mAb 84 is an antibody against Podocalyxin-like protein I (Cytotoxic) for use in Western Blotting, ICC, Flow Cytometry.

    merck millipore,默克密理博,MABD89,Anti-Podocalyxin-like protein I (Cytotoxic) Antibody, clone mAb 84

  • 产品介绍
  • merck millipore,默克密理博,MABD89,Anti-Podocalyxin-like protein I (Cytotoxic) Antibody, clone mAb 84

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFC, WB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABD89
    Replaces MAB4414
    描述 Anti-Podocalyxin-like protein I (Cytotoxic) Antibody, clone mAb 84
    Alternate Names
    • podocalyxin-like protein I, GCTM-2 antigen, Gp200
    背景信息 Podocalyxin-like protein 1 (PODXL) is a transmembrane protein known to be heavily sialyated and sulfated that is localized on the apical surface of podocytes and on vascular endothelia. Podocalyxin protein is expressed on the surface of undifferentiated human embryonic stem cells. Originally, the protein was characterized as a marker for vasculature and podocytes, but expression has since been observed in platelets, hematopoietic precursor cells and mesothelial cells from the coelmic cavity lining. Studies have outlined two distinct and seemingly adverse roles for this protein; it acts as an anti-adhesion molecule in renal glomerulae podocytes, but functions as an adhesion molecule within vasculature on high endothelial venules. Podocalyxin expression has been implicated in the development of aggressive cancers, beta catenin signaling, angiogenisis, and both myeloid and acute lymphoblastic leukemias.
    产品信息
    格式 Purified
    控制
    • H9 human embryonic stem cells.
    演示 Purified mouse monoclonal IgMκ in buffer containing PBS without preservatives.
    应用
    应用 Anti-Podocalyxin-like protein I (Cytotoxic) Antibody, clone mAb 84 is an antibody against Podocalyxin-like protein I (Cytotoxic) for use in Western Blotting, ICC, Flow Cytometry.
    主要应用
    • Flow Cytometry
    • Western Blotting
    • Immunocytochemistry
    应用说明 This antibody was shown to induce cell death of undifferentiated, but not differentiated hESC, within 30 minutes of incubation (Choo, A., et al. (2008). Stem Cells 26:1454-1463). This antibody has been shown to work in Western Blot applications (Choo, A., et al. (2008). Stem Cells, 26:1454–1463).
    This antibody has been shown to work in Flow Cytometry applications (Choo, AB., et al. (2008). Stem Cells, 26:1454–1463).
    生物信息
    免疫原品种 HES-3 Human embryonic stem cell line
    克隆 mab 84
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes the extracellular domain of Podocalyxin-like protein 1.
    This antibody has been shown to select against undifferentiated human embryonic stem cells (hESC) and to be functionally cytotoxic against these undifferentiated hESC populations (Choo, A., et al., 2008).
    同种型 IgMκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001018121
    基因符号
    • PCLP1
    • PCLP
    • Gp200
    • PC
    纯化方法 Purified by ion-exchange chromatography
    UniProt编号
    • O00592
    产品使用声明
    质量保证 Evaluated by Immunocytochemistry in H9 human embryonic stem cells. Immunocytochemistry Analysis: A 1:500 dilution of this antibody detected Podocalyxin-like protein I in H9 human embryonic stem cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABD89,Anti-Podocalyxin-like protein I (Cytotoxic) Antibody, clone mAb 84

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