merck millipore,默克密理愽
  • merck millipore,默克密理博,GF022,Transforming Growth Factor-α Protein, Recombinant human

  • merck millipore,默克密理博,GF022,Transforming Growth Factor-α Protein, Recombinant human

    产品名称：Transforming Growth Factor-α Protein, Recombinant human
    产品型号：GF022
    Transforming Growth Factor-a (TGF-a) is a polypeptide growth factor which stimulates the proliferation of a wide range or epidermal & epithelial cells.

    merck millipore,默克密理博,GF022,Transforming Growth Factor-α Protein, Recombinant human

  • 产品介绍
  • merck millipore,默克密理博,GF022,Transforming Growth Factor-α Protein, Recombinant human

    重要规格表

    主要应用 品种 来源 纯度
    CULTHumanE.coliGreater than 98% by SDS-PAGE and HPLC analyses
    描述
    产品目录编号 GF022
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Transforming Growth Factor-α Protein, Recombinant human
    概述 Transforming Growth Factor-a (TGF-a) is a polypeptide growth factor which stimulates the proliferation of a wide range or epidermal and epithelial cells. TGF-a has been shown a play a role in the autocrine growth of certain transformed cells. Human TGF-a is a 5.5 kDa protein containing 50 amino acid residues.
    Alternate Names
    • TGF-alpha
    产品信息
    演示 Lyophilized powder with no additives.
    应用
    应用 Transforming Growth Factor-a (TGF-a) is a polypeptide growth factor which stimulates the proliferation of a wide range or epidermal & epithelial cells.
    主要应用
    • Cell Culture
    应用说明 For most in vitro applications, TGFalpha exerts its biological activity in the concentration range of 0.5 to 25.0 ng/mL. Responding cells are (partial list): Epidermal, mesothelial cells.
    生物信息
    纯度 Greater than 98% by SDS-PAGE and HPLC analyses
    来源 E.coli
    品种 Human
    特异活性 Chemicon's human TGF-alpha, is fully biologically active when compared to standards. The ED(50) as determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is <=0.2 ng/mL, corresponding to a specific activity of >=5 x 10(E6) units/mg.
    Entrez基因编号
    • NM_003236.2
    • NM_001099691.1
    Entrez基因汇总 Transforming growth factors (TGFs) are biologically active polypeptides that reversibly confer the transformed phenotype on cultured cells. TGF-alpha shows about 40% sequence homology with epidermal growth factor (EGF; MIM 131530) and competes with EGF for binding to the EGF receptor (MIM 131550), stimulating its phosphorylation and producing a mitogenic response.[supplied by OMIM]
    基因符号
    • TFGA
    • TGFA
    UniProt编号
    • P01135
    UniProt汇总 FUNCTION: SwissProt: P01135 # TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
    SIZE: 160 amino acids; 17006 Da
    SUBUNIT: Interacts with the PDZ domains of SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface.
    SUBCELLULAR LOCATION: Transforming growth factor alpha: Secreted, extracellular space. & Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein.
    SIMILARITY: SwissProt: P01135 ## Contains 1 EGF-like domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 The lyophilized TGF-alpha, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other buffered solutions. Reconstituted TGF-alpha should be stored at 4°C for up to one week or at -20°C in undiluted aliquots for up to six months.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,GF022,Transforming Growth Factor-α Protein, Recombinant human

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