merck millipore,默克密理愽
  • merck millipore,默克密理博,204878,Complement C1r, Human, Activated, Two-Chain Form

  • merck millipore,默克密理博,204878,Complement C1r, Human, Activated, Two-Chain Form

    产品名称：Complement C1r, Human, Activated, Two-Chain Form
    产品型号：204878


    merck millipore,默克密理博,204878,Complement C1r, Human, Activated, Two-Chain Form

  • 产品介绍
  • merck millipore,默克密理博,204878,Complement C1r, Human, Activated, Two-Chain Form

    描述
    概述 Native, human, activated, C1r complement component. Generally the non-activated form composed of a single-chain glycoprotein. Present in normal human serum at 34 µg/ml. Non-activated C1r is found in circulating blood plasma as a dimer that associates with one C1q molecule and two C1s molecules to form the first component of complement (C1). Ensuing C1q binding to classical complement pathway activators, each C1r proenzyme monomer is activated by cleavage into two disulfide-linked fragments of M.W. 60,000 and 35,000. The 35 kDa peptide contains C1r enzymatic active site. Activated C1r continues activation via classical pathway by cleaving, and thus activating C1s.
    产品目录编号 204878
    品牌系列 Calbiochem®
    参考
    参考 Villiers, C.L., et al. 1983. Biochem. J. 215, 369.
    Ziccardi, R.J. and Cooper, N.R. 1976. J. Immunol. 116, 496.
    产品信息
    CAS号 80295-34-7
    形式 Liquid
    配方 In 140 mM NaCl, 10 mM imidazole, 2 mM EDTA, pH 7.4.
    Molar Mass 95000
    生物信息
    生物活性 ≥90% of C1r will bind with excess C1-INH
    纯度 ≥90% by SDS-PAGE
    来源 Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
    浓缩标签 Please refer to vial label for lot-specific concentration
    理化信息
    污染物 IgG, IgA, IgM, albumin, C1s, C4BP, C1-INH: ≤trace amounts
    储存和货运信息
    货运代码 Dry Ice Only
    毒性 Standard Handling
    储存 ≤ -70°C
    避免冻结 / 解冻 Avoid freeze/thaw
    无需冷冻 No
    特殊指南 Following initial thaw, aliquot and freeze (-70°C).

    merck millipore,默克密理博,204878,Complement C1r, Human, Activated, Two-Chain Form

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