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品种反应性 主要应用 宿主 格式 抗体类型 M, H, R FC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MABD22 描述 Anti-MSX2 Antibody, clone 7D11.1 Alternate Names - Homeobox protein Hox-8
- Homeobox protein MSX-2
背景信息 MSX2, also known as HOX-8, is a homeobox containing transcription factor, which is a member of the MSH family of homeobox proteins, and is expressed at sites of epithelial-mesenchymal interaction during embryogenesis. More specifically, MSX2 has been found to be expressed in the epidermis, hair follicles, and fibroblasts of the developing fetal skin, and is detected as a diffuse cytoplasmic signal in fetal epidermis and portions of the hair follicle and dermis. In adult epidermis, however, MSX2 expression is localized to the nucleus. More recently, when in combination with another homeobox gene, MSX1, MSX2 has been shown to play a critical role in the developmental stages of both neural tube and neural crest, suggesting that both the MSX1 and the MSX2 genes play an important role in organogenesis. 产品信息 格式 Purified 控制 - HeLa cell lysate
演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-MSX2 Antibody, clone 7D11.1 is an antibody against MSX2 for use in WB, FC. 主要应用 - Flow Cytometry
- Western Blotting
应用说明 Flow Cytometry Analysis: A previous lot of this antibody was used to detect MSX2 in HeLa cells. 生物信息 免疫原品种 GST-tagged recombinant protein corresponding to human MSX2. 克隆 7D11.1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2bκ 品种反应性 MouseHumanRat Species Reactivity Note Demonstrated to react with Human, Rat, and Mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_002440
Entrez基因汇总 This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq]. 基因符号 - HOX8
- MSX2
纯化方法 Protein G purified UniProt编号 - P35548
UniProt汇总 FUNCTION: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.
SUBUNIT STRUCTURE: Interacts with MINT By similarity. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80).
SUBCELLULAR LOCATION: Nucleus.
INVOLVEMENT IN DISEASE: Defects in MSX2 are the cause of parietal foramina 1 (PFM1) [MIM:168500]; also known as foramina parietalia permagna (FPP). PFM1 is an autosomal dominant disease characterized by oval defects of the parietal bones caused by deficient ossification around the parietal notch, which is normally obliterated during the fifth fetal month. Defects in MSX2 are the cause of parietal foramina with cleidocranial dysplasia (PFMCCD) [MIM:168550]; also known as cleidocranial dysplasia with parietal foramina. PFMCCD combines skull defects in the form of enlarged parietal foramina and deficient ossification of the clavicles. Ref.12
Defects in MSX2 are the cause of craniosynostosis type 2 (CRS2) [MIM:604757]; also known as craniosynostosis Boston-type (CSB). CRS2 is an autosomal dominant disorder characterized by the premature fusion of calvarial sutures. The craniosynostosis phenotype is either fronto-orbital recession, or frontal bossing, or turribrachycephaly, or cloverleaf skull. Associated features include severe headache, high incidence of visual problems (myopia or hyperopia), and short first metatarsals. Intelligence is normal.
SEQUENCE SIMILARITIES: Belongs to the Msh homeobox family.
Contains 1 homeobox DNA-binding domain.产品使用声明 质量保证 Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 2 µg/mL of this antibody detected MSX2 on 10 µg of HeLa cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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