merck millipore,默克密理博,219482,Caveolin-1 Scaffolding Domain Peptide, Cell-permeable

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merck millipore,默克密理博,219482,Caveolin-1 Scaffolding Domain Peptide, Cell-permeable - Calbiochem
产品名称：Caveolin-1 Scaffolding Domain Peptide, Cell-permeable - Calbiochem
产品型号：219482
Caveolin-1 scaffolding domain peptide (C1-SD82-101) fused at the N-terminus to the cell-permeable Antennapedia internalization sequence (43-58).

merck millipore,默克密理博,219482,Caveolin-1 Scaffolding Domain Peptide, Cell-permeable - Calbiochem

产品介绍

merck millipore,默克密理博,219482,Caveolin-1 Scaffolding Domain Peptide, Cell-permeable - Calbiochem

重要规格表

经验配方
C₂₂₈H₃₃₅N₆₁O₄₉S

描述
概述	Caveolin-1 scaffolding domain peptide (C1-SD_82-101) fused at the N-terminus to the cell-permeable Antennapedia internalization sequence (43-58). This peptide is reported to block eNOS activity and cellular NO release in vitro and reduce inflammation and tumorigenesis in vivo. Caveolin-1 interacts with several lipid-modified signaling ligands, such as EGFR, eNOS, G-protein α-subunits, PKCα, H-Ras, and Src, via the C1-SD_82-101 sequence.
产品目录编号	219482
品牌系列	Calbiochem®
同义词	AP-Cav, Pen-C1-SD, RQIKIWFQNRRMKWKK-DGIWKASFTTFTVTKYWFYR, Cavtratin

参考
参考	Bernatchez, P.N., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 761. Williams, T.M., et al. 2004. J. Biol. Chem. 279, 51630. Gratton, J.P., et al. 2003. Cancer Cell 4, 31. Sukumaran, S.K., et al. 2002. J. Biol. Chem. 277, 50716. Liu, J., et al. 2002. J. Biol. Chem. 277, 10661. Bucci, M., et al. 2000. Nat. Med. 6, 1362. Okamoto, T., et al. 1998. J. Biol. Chem. 273, 5419.

参考

Bernatchez, P.N., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 761.
Williams, T.M., et al. 2004. J. Biol. Chem. 279, 51630.
Gratton, J.P., et al. 2003. Cancer Cell 4, 31.
Sukumaran, S.K., et al. 2002. J. Biol. Chem. 277, 50716.
Liu, J., et al. 2002. J. Biol. Chem. 277, 10661.
Bucci, M., et al. 2000. Nat. Med. 6, 1362.
Okamoto, T., et al. 1998. J. Biol. Chem. 273, 5419.

产品信息
具有ATP竞争性	N
形式	White lyophilized solid
配方	Supplied as a trifluoroacetate salt.
Hill配方	C₂₂₈H₃₃₅N₆₁O₄₉S
化学配方	C₂₂₈H₃₃₅N₆₁O₄₉S
Molar Mass	4746.6
吸湿	Hygroscopic
肽序列	H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Asp-Gly-Ile-Trp-Lys-Ala-Ser-Phe-Thr-Thr-Phe-Thr-Val-Thr-Lys-Tyr-Trp-Phe-Tyr-Arg-OH
可逆	N

生物信息
主靶	eNOS
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO
肽序列	H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Asp-Gly-Ile-Trp-Lys-Ala-Ser-Phe-Thr-Thr-Phe-Thr-Val-Thr-Lys-Tyr-Trp-Phe-Tyr-Arg-OH

储存和货运信息
货运代码	Shipped with Blue Ice or with Dry Ice
毒性	Carcinogenic / Teratogenic
储存	-20°C
避光	Protect from light
吸湿	Hygroscopic
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.