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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M IHC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-394 品牌系列 Upstate
商名 - Upstate
描述 Anti-MAGE-D1/NRAGE Antibody 产品信息 格式 Serum 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide, before the addition of glycerol to 30% 应用 应用 Anti-MAGE-D1/NRAGE Antibody is an antibody against MAGE-D1/NRAGE for use in IP, WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 GST fusion protein corresponding to residues 53-295 of rat MAGE-D1/NRAGE 宿主 Rabbit 特异性 NRAGE/MAGE-D1 同种型 IgG 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_006986
Entrez基因汇总 This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. 基因符号 - DLXIN-1
- MAGED1
- PP2250
- NRAGE
纯化方法 Antiserum UniProt编号 - Q9Y5V3
UniProt汇总 FUNCTION: SwissProt: Q9Y5V3 # Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate p53 transcriptional activity and inhibit cell proliferation. Enhances p53 phosphorylation and accumulation.
SIZE: 778 amino acids; 86161 Da
SUBUNIT: Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A (By similarity). Interacts with the p75 neurotrophin receptor.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF (By similarity).
TISSUE SPECIFICITY: Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
SIMILARITY: SwissProt: Q9Y5V3 ## Contains 1 MAGE domain.产品使用声明 质量保证 routinely evaluated by immunoblot in RIPA lysates from PC12 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µL
上一件merck millipore产品：merck millipore,默克密理博,MABD22,Anti-MSX2 Antibody, clone 7D11.1
下一件merck millipore产品：merck millipore,默克密理博,219482,Caveolin-1 Scaffolding Domain Peptide, Cell-permeable - Calbiochem
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