merck millipore,默克密理愽
  • merck millipore,默克密理博,14-725,EGFR (T790M) Protein, active, 10 µg

  • merck millipore,默克密理博,14-725,EGFR (T790M) Protein, active, 10 µg

    产品名称：EGFR (T790M) Protein, active, 10 µg
    产品型号：14-725
    Active, N-terminal GST-tagged recombinant human EGF Receptor, amino acids 696end containing the mutation T790M, for use in Enzyme Assays.

    merck millipore,默克密理博,14-725,EGFR (T790M) Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-725,EGFR (T790M) Protein, active, 10 µg

    描述
    产品目录编号 14-725
    品牌系列 Upstate
    商名
    • Upstate
    描述 EGFR (T790M) Protein, active, 10 µg
    概述 N-terminal GST-tagged recombinant human EGF Receptor, amino acids 696end containing the mutation T790M
    应用
    应用 Active, N-terminal GST-tagged recombinant human EGF Receptor, amino acids 696end containing the mutation T790M, for use in Enzyme Assays.
    主要应用
    • Enzyme Assay
    生物信息
    来源 expressed by baculovirus in Sf21 cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_201284.1
    • NM_005228.3
    • NM_201282.1
    • NM_201283.1
    基因符号
    • mENA
    • EGFR
    • ERBB1
    • ERBB
    蛋白靶 EGFR
    纯化方法 Glutathione-agarose
    靶子系列 TK
    UniProt编号
    • P00533
    UniProt汇总 FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.
    SIZE: 1210 amino acids; 134277 Da
    SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.
    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
    TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.
    PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].
    SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
    MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of 250μM substrate peptide (GGMEDIYFEFMGGKKK)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C from date of shipment
    包装信息
    数量 10 µg

    merck millipore,默克密理博,14-725,EGFR (T790M) Protein, active, 10 µg

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