• merck millipore,默克密理博,ABS527,Anti-Sphk2, C-term Antibody
  • merck millipore,默克密理博,ABS527,Anti-Sphk2, C-term Antibody

    产品名称:Anti-Sphk2, C-term Antibody
    产品型号:ABS527
    This Anti-Sphk2, C-term Antibody is validated for use in Western Blotting and Immunoprecipitation and Immunocytochemistry for the detection of Sphk2, C-term.

    merck millipore,默克密理博,ABS527,Anti-Sphk2, C-term Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABS527,Anti-Sphk2, C-term Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MICC, WBRbSerumPolyclonal Antibody
    描述
    产品目录编号 ABS527
    描述 Anti-Sphk2, C-term Antibody
    Alternate Names
    • SPK 2
    • Sphingosine kinase 2
    • SK 2
    背景信息 Sphingosine kinase 2 (Sphk2), along with its sister enzyme Sphk1, is an important kinase needed to form the important intra and extracellular signaling lipid mediator and neuroprotective factor SPP/S1P (sphingosine 1-phosphate). Sphk2 is important in blood vessel development, brain development, as well as an anti-apoptotic factor, and it mediates many proliferation mediated responses such as those surrounding insulin and its mitogenic ability. Sphk2 is localized to the lysosome membrane primarily but can also be found in the cytoplasm. Interestingly, recent research indicates that ApoE regulates the secretion Sphingosine 1-phosphate in the brain, and SPP/S1P in turn positively regulates glutamate secretion and synaptic strength in hippocampal neurons, thus Sphk1/2 plays an important role in synaptic plasticity and neuronal activity connectivity in the brain as well.
    产品信息
    格式 Serum
    演示 Rabbit polyclonal serum with 0.05% sodium azide.
    应用
    应用 This Anti-Sphk2, C-term Antibody is validated for use in Western Blotting and Immunoprecipitation and Immunocytochemistry for the detection of Sphk2, C-term.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Sphk2 in 10 µg of mouse lung tissue lysate.
    Western Blotting Analysis: A representative lot detected Sphk2 in mouse BMMC tissue lysate (Olivera, A., et al. (2006). JBC. 281(5):2515-2525).
    Immunoprecipitation Analysis: A representative lot immunoprecipitated Sphk2 in mouse BMMC tissue lysate (Olivera, A., et al. (2006). JBC. 281(5):2515-2525).
    Immunocytochemistry Analysis: A representative lot detected Sphk2 in Huvec cells (Venkataraman, K., et al. (2006) Biochem. J. 397:461-471).
    生物信息
    免疫原品种 Recombinant protein corresponding to the C-terminus of mouse Sphk2, C-term.
    表位 C-terminus
    宿主 Rabbit
    品种反应性 Mouse
    Species Reactivity Note Mouse.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001166032
    基因符号
    • Sphk2
    纯化方法 Unpurified
    UniProt编号
    • Q9JIA7
    产品使用声明
    质量保证 Evaluated by Western Blotting in RAW264.7 cell lysate.

    Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Sphk2, C-term in 10 µg of RAW264.7 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,ABS527,Anti-Sphk2, C-term Antibody

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