merck millipore,默克密理愽
  • merck millipore,默克密理博,346110,Glucocorticoid Receptor Modulator, CpdA - CAS 14593-25-0 - Calbiochem

  • merck millipore,默克密理博,346110,Glucocorticoid Receptor Modulator, CpdA - CAS 14593-25-0 - Calbiochem

    产品名称：Glucocorticoid Receptor Modulator, CpdA - CAS 14593-25-0 - Calbiochem
    产品型号：346110
    A cell-permeable aziridine precursor that acts as a nonsteroidal glucocorticoid receptor ligand with a binding affinity that is 4-fold higher than that of Dexamethasone.

    merck millipore,默克密理博,346110,Glucocorticoid Receptor Modulator, CpdA - CAS 14593-25-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,346110,Glucocorticoid Receptor Modulator, CpdA - CAS 14593-25-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₁H₁₄ClNO₂ • HCl14593-25-0
    描述
    概述 A cell-permeable aziridine precursor that acts as a nonsteroidal glucocorticoid receptor (GR, Cat. No. 346100) ligand with a binding affinity that is 4-fold higher than that of Dexamethasone (DEX, Cat. No. 265005). Induces GR nuclear translocation and selectively activates GR-mediated transrepression of the NF-κB-dependent production of pro-inflammatory cytokines. Unlike DEX, CpdA exhibits no effect on GRE- (glucocorticoid response element) driven gene expression. Reported to be as effective as DEX in suppressing acute inflammation in mice in vivo without the hyperglycemic side effect that is commonly associated with DEX.
    产品目录编号 346110
    品牌系列 Calbiochem®
    同义词 2-((4-Acetoxyphenyl)-2-chloro-N-methyl)ethylammonium chloride
    参考
    参考 De Bosscher, K., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 15827.
    产品信息
    CAS号 14593-25-0
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₁₁H₁₄ClNO₂ • HCl
    化学配方 C₁₁H₁₄ClNO₂ • HCl
    Molar Mass 264.2
    可逆 N
    结构配方图像
    生物信息
    主靶 A nonsteroidal glucocorticoid receptor (GR, Cat. No. 346100) ligand
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO, EtOH, or H₂O
    储存和货运信息
    货运代码 Dry Ice Only
    毒性 Standard Handling
    储存 ≤ -70°C
    防潮 Protect from moisture
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-70°C). Ethanol stock solutions are stable for up to 1 month at -70°C.

    merck millipore,默克密理博,346110,Glucocorticoid Receptor Modulator, CpdA - CAS 14593-25-0 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,693015,ZWITTERGENT 3-12 Detergent - CAS 14933-08-5 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,MABS178,Anti-STK39 Antibody, clone 5H7.1


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