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merck millipore,默克密理博,MABC592,Anti-TRP1/TYRP1 Antibody, clone TA99, Azide Free
产品名称：Anti-TRP1/TYRP1 Antibody, clone TA99, Azide Free
产品型号：MABC592
This Anti-TRP1/TYRP1 Antibody, clone TA99, Azide Free is validated for use in western blotting, IHC, blocking of inteferring antibodies, IP & flow cytometry for the detection of TRP1/TYRP1.
merck millipore,默克密理博,MABC592,Anti-TRP1/TYRP1 Antibody, clone TA99, Azide Free
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, M FC, WB, IHC M Purified Monoclonal Antibody 描述 产品目录编号 MABC592 描述 Anti-TRP1/TYRP1 Antibody, clone TA99, Azide Free Alternate Names - TRP1
- 5,6-dihydroxyindole-2-carboxylic acid oxidase
- DHICA oxidase
- Catalase B
- Glycoprotein 75
- Melanoma antigen gp75
- Tyrosinase-related protein 1
- TRP
- TRP-1
背景信息 TRP1/TYRP1, also known as 5,6-dihydroxyindole-2-carboxylic acid oxidase, DHICA, Catalase B, Glycoprotein 75, Melanoma antigen gp75, or Tyrosinase-related protein 1 (TRP/TRP-1/TRP1), and encoded by the gene TYRP1/CAS2/TYRP/TYRRP, is involved in melanin synthesis and is the enzyme that oxidizes DHICA into indole-5,6-quinone-2-carboxylic acid in the pathway. TRP1/TYRP1 is critical for skin/eye/hair pigmentation. Mutations are associated with Albinism. TRP1/TYRP1 is regulated by the microphthalmia-associated transcription factor (MITF). MITF is a master regulator of pigmentation and a target of β-catenin in Wnt/β-catenin signaling during melanocyte differentiation. TRP1/TYRP1 is also regulated by the microRNA miR-145, and this microRNA is being examined as a possible therapy for hyperpigmentation. TRP1/TYRP1 is expressed as a membrane protein in melanosomes and endosomes in pigment cells. 产品信息 格式 Purified 演示 Purified mouse monoclonal IgG2aκ in buffer containing PBS without preservatives. 应用 应用 This Anti-TRP1/TYRP1 Antibody, clone TA99, Azide Free is validated for use in western blotting, IHC, blocking of inteferring antibodies, IP & flow cytometry for the detection of TRP1/TYRP1. 主要应用 - Flow Cytometry
- Western Blotting
- Immunohistochemistry
应用说明 Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TRP1/TYRP1 in human melanoma tissue.
Blocking of Interferring Antibodies Analysis: A representative lot from an independent laboratory suppressed the growth of subcutaneous B16 tumors (Patel, D., et al. (2008). Anticancer Res. 28(5A):2679-2686.).
Activity Assay Analysis: A representative lot from an independent laboratory improves anti-tumor efficacy by augmenting systemic CD8+T cell responses to tumor cells (Saenger, Y. M., et al. (2008). Cancer Res. 68(23):9884-9891.).
Immunoprecipiptation Analysis: A representative lot from an independent laboratory immunoprecipiated TRP1/TYRP1 from B16 cell lysate (Srinivasan, R., et al. (2002). Cancer Immun. 19(2):8.).生物信息 免疫原品种 Whole cells corresponding to human TRP1/TYRP1. 克隆 TA99 浓缩 1 mg/mL 宿主 Mouse 同种型 IgG2aκ 品种反应性 HumanMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_000541
基因符号 - TYRRP
- TYRP1
- CAS2
- TYRP
纯化方法 Protein G purified UniProt编号 - P17643
产品使用声明 质量保证 Evaluated by Western Blottng in mouse skin tissue lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected TRP1/TYRP1 in 10 µg of mouse skin tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µg
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