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描述 产品目录编号 14-572M 品牌系列 Upstate
商名 - Upstate
描述 PLK3 Protein, active, 250 µg 概述 N-terminal His6-tagged recombinant human Plk3, residues 19-301 应用 应用 Active, N-terminal His6-tagged recombinant human Plk3, residues 19-301, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed by baculovirus in Sf21 insect cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_004073.2
Entrez基因汇总 Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis. 基因符号 - PRK
- PLK3
- CNK
- PLK-3
- FNK
蛋白靶 PLK3 纯化方法 Ni2+/NTA-agarose 靶子系列 AGC UniProt编号 - Q9H4B4
UniProt汇总 FUNCTION: SwissProt: Q9H4B4 # Serine/threonine protein kinase involved in regulating M phase functions during the cell cycle. May also be part of the signaling network controlling cellular adhesion. In vitro, is able to phosphorylate CDC25C and casein.
SIZE: 646 amino acids; 71629 Da
SUBUNIT: Binds to the calcium/integrin-binding protein (CIB). This interaction probably occurs via the POLO-box domain.
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. May have a short half-live. In cells of hematopoietic origin, strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor.
PTM: Phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis (By similarity).
SIMILARITY: SwissProt: Q9H4B4 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. & Contains 2 POLO box domains. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of Casein 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-572) and in bulk (cat# 14-572-K).
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