merck millipore,默克密理博,07-2101,Anti-phospho PIX Antibody (Ser340)

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merck millipore,默克密理博,07-2101,Anti-phospho PIX Antibody (Ser340)
产品名称：Anti-phospho PIX Antibody (Ser340)
产品型号：07-2101
This phospho PIX antibody is validated for use in WB for the detection of the phospho PIX protein.

merck millipore,默克密理博,07-2101,Anti-phospho PIX Antibody (Ser340)

产品介绍

merck millipore,默克密理博,07-2101,Anti-phospho PIX Antibody (Ser340)

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	07-2101
描述	Anti-phospho PIX Antibody (Ser340)
Alternate Names	P50 Rho guanine nucleotide exchange factor (GEF) 7 PAK-interacting exchange factor beta guanine nucleotide exchange factor 7 rho guanine nucleotide exchange factor 7 SH3 domain-containing proline-rich protein p85 PAK3 Beta-Pix P85COOL1 COOL-1 P85 PAK3BP
背景信息	p-21-activated kinase (PAK) interacting exchange factor (PIX) is a guanine nucleotide exchange factor. PIX is a necessary component for the recruitment, regulation and activation of Rac1, as it is able to directly bind Rac1 via its SH3 domain. Studies indicate that PIX may also have an active role as a positive regulator of apoptosis, an inducer of membrane ruffling and in cell migration. Along with Rac1, PIX has been shown to regulate and interact with GIT1 and NOD2. Alternative splicing and initiation give rise to 8 known isoforms. Expression of PIX has been localized to the central nervous system. Isoforms B, C and E have highest expression in the testis and brain.

产品信息
格式	Affinity Purified
控制	PIX transfected cell lysates
演示	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide, 1 mg/mL BSA and 30% glycerol.

应用
应用	This phospho PIX antibody is validated for use in WB for the detection of the phospho PIX protein.
主要应用	Western Blotting

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to mouse PIX phosphorylated at Ser340.
表位	Phosphorylated Ser340
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	This antibody recognizes PIX phosphorylated at Ser340.
同种型	IgG
品种反应性	Mouse
Species Reactivity Note	Demonstrated to react with mouse. Predicted to react with human and rat based on 100% sequence homology.
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_001106989
基因符号	P50 PIXB COOL1 P50BP BETA-PIX p85 PAK3 Beta-Pix P85COOL1 COOL-1 P85 PAK3BP
修改	Phosphorylation
纯化方法	Affinity Purfied
UniProt编号	Q9ES28
UniProt汇总	FUNCTION: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. May function in cell migration (by similarity). SUBUNIT STRUCTURE: Interacts with PAK kinases through the SH3 domain. Interacts with unphosphorylated PAK1. Interacts with ITCH. Interacts with SCRIB; interaction is direct and may play a role in regulation of apoptosis by similarity. Interacts with GIT1 and TGFB1I1. Interacts with FRMPD4 (via N-terminus) (by similarity). TISSUE SPECIFICITY: Seems to be expressed in the central nervous system. Isoform B, isoform C and isoform E are expressed with highest levels in brain and testis. SEQUENCE SIMILARITIES: Contains 1 CH (calponin-homology) domain. Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 SH3 domain.

产品使用声明
质量保证	Evaluated by Western Blot in PIX transfected cell lysates. Western Blot Analysis: A 1:1000 dilution of this antibody detected PIX on 10 µg of Pix transfected cell lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.