merck millipore,默克密理愽
  • merck millipore,默克密理博,MABC521,Anti-XBP1s Antibody, clone 143F (active form)

  • merck millipore,默克密理博,MABC521,Anti-XBP1s Antibody, clone 143F (active form)

    产品名称：Anti-XBP1s Antibody, clone 143F (active form)
    产品型号：MABC521
    Anti-XBP1s Antibody, clone 143F (active form) is an antibody against XBP1s for use in IHC & western blotting.

    merck millipore,默克密理博,MABC521,Anti-XBP1s Antibody, clone 143F (active form)

  • 产品介绍
  • merck millipore,默克密理博,MABC521,Anti-XBP1s Antibody, clone 143F (active form)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABC521
    描述 Anti-XBP1s Antibody, clone 143F (active form)
    Alternate Names
    • Tax-responsive element-binding protein 5
    • X-box-binding protein 1
    • XBP-1
    背景信息 XBP-1, also known as X-box-binding protein 1 or Tax-responsive element-binding protein 5, and encoded by the gene XBP1/TREB5/XBP2, is a transcription factor essential for hepatocyte growth, the differentiation of plasma cells, immunoglobulin secretion, and the unfolded protein response (UPR). XBP-1 also acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). XBP-1 binds DNA preferentially at CRE-like elements but also to some TPA response elements (TRE). XBP-1 is expressed in the nucleus. Defects in XBP-1 may be associated with Major affective disorder 7 (MAFD7) a major psychiatric disorder that is characterized by severe mood swings, with fluctuation between two abnormal mood states (manic or major depressive episode). Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy.
    产品信息
    格式 Purified
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-XBP1s Antibody, clone 143F (active form) is an antibody against XBP1s for use in IHC & western blotting.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Western Blotting Analyis: A representative lot from an independent laboratory detected XBP-1S, clone 143F (active form) in SK-MM-2, KARPAS 620, NCI-H929, and LP-1 cell lysates (Maestre, L., et al. (2009). Haematologica. 94(3):419-422.).

    Immunohistochemistry Analysis: A representative lot from an independent laboratory detected XBP-1S, clone 143F (active form) in human tonsil and lymphoplasmacytic cells (Maestre, L., et al. (2009). Haematologica. 94(3):419-422.).
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to the C-terminus of human XBP-1S, clone 143F (active form).
    表位 C-terminus
    克隆 143F
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2aκ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001073007
    基因符号
    • XBP2
    • XBP1
    • TREB5
    纯化方法 Protein G purified
    UniProt编号
    • P17861
    产品使用声明
    质量保证 Evaluated by Immunohistochemistry in human skin tissues.

    Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected XBP-1S, clone 143F (active form) in human skin tissues.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABC521,Anti-XBP1s Antibody, clone 143F (active form)

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