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merck millipore,默克密理博,MABC166,Anti-Angiogenin Antibody, clone 26–2F (Azide Free)
产品名称：Anti-Angiogenin Antibody, clone 26–2F (Azide Free)
产品型号：MABC166
This Anti-Angiogenin Antibody, clone 26–2F (Azide Free) is validated for use in Immunocytochemistry and Inhibition and Immunohistochemistry for the detection of Angiogenin.
merck millipore,默克密理博,MABC166,Anti-Angiogenin Antibody, clone 26–2F (Azide Free)
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, ICC M Purified Monoclonal Antibody 描述 产品目录编号 MABC166 描述 Anti-Angiogenin Antibody, clone 26–2F (Azide Free) Alternate Names - RNase 5
- Angiogenin
- Ribonuclease 5
背景信息 Angiogenin (Ang) is a non-glycosylated polypeptide, 123 amino acids in length, with a molecular mass of 14 kDa. It is secreted by tumor cells and is a potent inducer of neovascularization. Angiogenin is produced by a variety of cell types including vascular endothelial cells and smooth muscle cells, fibroblasts, tumor colonic epithelium, normal peripheral blood lymphocytes, lung and colonic epithelial tumor cell lines, and primary gastrointestinal adenocarcinomas. It specifically binds to endothelial cells and elicits second messenger systems. Angiogenin is present in human follicular fluid, and its production is up-regulated by human chorionic gonadotropin and hypoxic conditions. Angiogenin shows a high degree of homology with known ribonucleases such as pancreatic ribonuclease A, and the capacity of angiogenin to induce blood vessel growth is dependent on its ribo-nucleolytic activity. Angiogenin is thought to be involved in the development of solid tumors; angiogenin antagonists are capable of inhibiting tumor growth. Angiogenin is endocytosed by subconfluent endothelial cells and translocated to the nucleus, where it accumulates in the nucleolus. Serum angiogenin concentration is increased in serum of colorectal cancer patients, and correlates with cancer progression. The cytoskeletal protein α-actinin-2 binds to angiogenin, which might be a novel interface target for anti-angiogenesis and anti-tumor therapy. 产品信息 格式 Purified 演示 Purified mouse monoclonal IgG1κ in buffer containing PBS without preservatives. 应用 应用 This Anti-Angiogenin Antibody, clone 26–2F (Azide Free) is validated for use in Immunocytochemistry and Inhibition and Immunohistochemistry for the detection of Angiogenin. 主要应用 - Immunohistochemistry
- Immunocytochemistry
应用说明 Inhibition Assay: A representative lot of this antibody blocked cell-free protein synthesis by angiogenin (Fett et al., (1994) Biochemistry. 33(18):5421-5427).
Inhibition Assay: A representative lot of this antibody inhibited ribonucleolytic activity (Piccoli et al., (1998) Proc. Natl. Acad. Sci. 95:4579–4583).
Immunohistochemistry Analysis: A representative lot of this antibody detected Angiogenin in Neovessels of cancer tissue (Tsuji et al., (2005) Cancer Res. 65:1352-1360).
Immunocytochemistry Analysis: A representative lot of this antibody detected Angiogenin in HeLa and Huvec cells (Tsuji et al., (2005) Cancer Res. 65:1352-1360).生物信息 免疫原品种 Purified Human Angiogenin. 克隆 26-2F 浓缩 Please refer to lot specific datasheet. 宿主 Mouse 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001091046
基因符号 - RNASE5
- ANG
纯化方法 Protein G purified UniProt编号 - P03950
产品使用声明 质量保证 Evaluated by Immunocytochemistry in HeLa cells.
Immunocytochemistry Analysis: A 4 µg/mL of this antibody detected Angiogenin in Angiogenin-treated and untreated HeLa Cells. HeLa cells that were treated with Angiogenin up-took the protein and translocated it to the nucleus. Untreated HeLa cells did not exhibit any Angiogenin protein signal.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µg
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