merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB8878,Anti-Cdk1 Antibody, clone A17.1.1

  • merck millipore,默克密理博,MAB8878,Anti-Cdk1 Antibody, clone A17.1.1

    产品名称：Anti-Cdk1 Antibody, clone A17.1.1
    产品型号：MAB8878
    Anti-Cdk1 Antibody, clone A17.1.1 is a Mouse Monoclonal Antibody for detection of Cdk1 also known as p34cdc2, CDC2 & has been validated in IF, IP, EA, WB, IHC(P).

    merck millipore,默克密理博,MAB8878,Anti-Cdk1 Antibody, clone A17.1.1

  • 产品介绍
  • merck millipore,默克密理博,MAB8878,Anti-Cdk1 Antibody, clone A17.1.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Xn, Ch, H, M, RWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB8878
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Cdk1 Antibody, clone A17.1.1
    Alternate Names
    • CDC2
    • p34cdc2
    产品信息
    格式 Purified
    控制
    • POSITIVE CONTROL:

      HeLa or NIH3T3 cells. Germinal center in a tonsil or reactive lymph node. Cellular localization is predominantly nuclear, with some cytoplasmic staining.
    演示 Purified immunoglobulin. 0.2 mg/mL in 10 mM PBS, pH 7.4, containing 0.2% BSA and 0.09% Sodium Azide.
    应用
    应用 Anti-Cdk1 Antibody, clone A17.1.1 is a Mouse Monoclonal Antibody for detection of Cdk1 also known as p34cdc2, CDC2 & has been validated in IF, IP, EA, WB, IHC(P).
    主要应用
    • Western Blotting
    应用说明 Frozen Sections

    Immunofluorescence

    Immunoprecipitation: (Native/denatured, Protein A; 2μg/mg protein lysate)

    Immunohistology (Formalin, 2-4μg/mL for 30 min at RT)

    Paraffin Sections (staining requires antigen retrieval).

    Western Blotting

    Kinase Assay

    Optimal working dilutions must be determined by the end user.

    p34cdc2, a serine/threonine kinase, is activated by cyclins, presumably by dephosphorylation of tyrosine residues. MAB8878 inhibits the activation of p34cdc2 kinase by cyclins and precipitates an active kinase.
    生物信息
    免疫原品种 Raised against Xenopus p34cdc2.
    克隆 A17.1.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes a 34 kDa protein cdk1, identified as cdk1/p34cdc2 protein kinase (a catalytic subunit of Maturation Promoting Factor). Its epitope maps near the C-terminus of protein and its core is thought to be LGTPNNEV. It shows no cross-reaction with cdk2/p32 and other cyclin dependent kinases (cdks).
    同种型 IgG2a
    品种反应性 XenopusChickenHumanMouseRat
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_033379.2
    • NM_001786.2
    Entrez基因汇总 The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.
    基因符号
    • EC 2.7.11.23
    • CDC2
    • CDK1
    • DKFZp686L20222
    • MGC111195
    • CDC28A
    • EC 2.7.11.22
    UniProt编号
    • P06493
    UniProt汇总 FUNCTION: SwissProt: P06493 # Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.
    SIZE: 297 amino acids; 34095 Da
    SUBUNIT: Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with DLG7. Isoform 2 is unable to complex with cyclin B1 and also fails to bind to the CDK inhibitor p21. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase.
    SUBCELLULAR LOCATION: Nucleus (By similarity).
    SIMILARITY: SwissProt: P06493 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2° to 8°C in undiluted aliquots for up to 12 months from date of receipt.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,MAB8878,Anti-Cdk1 Antibody, clone A17.1.1

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