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merck millipore,默克密理博,MAB88079,Anti-Heat Shock Factor II Antibody, clone 3E2
产品名称：Anti-Heat Shock Factor II Antibody, clone 3E2
产品型号：MAB88079
Anti-Heat Shock Factor II Antibody, clone 3E2 is an antibody against Heat Shock Factor II for use in ELISA, IF, IP & WB.
merck millipore,默克密理博,MAB88079,Anti-Heat Shock Factor II Antibody, clone 3E2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Mk, H, M WB, ELISA R Purified Monoclonal Antibody 描述 产品目录编号 MAB88079 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Heat Shock Factor II Antibody, clone 3E2 Alternate Names - HSFII
产品信息 格式 Purified 控制 - POSITIVE CONTROL:
NIH-3T3 cells
演示 Purified immunoglobulin. Liquid containing 10 mM PBS, pH 7.4, with 0.2% BSA and 15 mM sodium azide. 应用 应用 Anti-Heat Shock Factor II Antibody, clone 3E2 is an antibody against Heat Shock Factor II for use in ELISA, IF, IP & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Immunofluorescence Immunohistology (predominantly cytoplasmic with some nuclear). Immunoprecipitation: 2 μg/mg protein lysate. Western blot. 1:200-1:400 ELISA
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Full length recombinant mouse HSF2 proteins (aa 1-517) 克隆 3E2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 特异性 MAB88079 recognizes a protein of 70 kDa, identified as Heat Shock Factor 2 (HSF2). The synthesis of heat shock proteins is dependent on transcriptional and post-transcriptional control in eukaryotic cells. The regulation of heat shock gene transcription is mediated by the transcriptional activator, Heat Shock Factor (HSF), which binds to heat shock response elements (HSEs). At least three HSFs have been isolated from the human, mouse, chicken, and tomato genomes and an additional factor, HSF4 has been identified in humans. HSFs purified from yeast, Drosphila, and human have different molecular weights and do not cross-react immunologically. These factors are activated by distinct stimuli. HSF1 responds to cellular stress signals such as heat, heavy metals, and oxidative reagents whereas, the HSF2 is activated during differentiation. some laboratories have reported that the constitutive, non-DNA binding, monomeric form of inactive HSF1 is located in the cytoplasm. Upon activation, HSF1 is trimerized and is localized in nucleus where it binds DNA. the phosphorylation of HSF1 may be necessary for maximal transcription of heat shock genes. 同种型 IgG2a 品种反应性 MonkeyHumanMouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_004506.2
Entrez基因汇总 HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors. 基因符号 - MGC156196
- HSF2
- MGC117376
- MGC75048
- HSTF2
UniProt编号 - Q03933
UniProt汇总 FUNCTION: SwissProt: Q03933 # DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
SIZE: 536 amino acids; 60348 Da
SUBUNIT: DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon activation.
SIMILARITY: SwissProt: Q03933 ## Belongs to the HSF family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. 包装信息 数量 50 µg
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