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merck millipore,默克密理博,233630,Cryptotanshinone - CAS 35825-57-1 - Calbiochem
产品名称：Cryptotanshinone - CAS 35825-57-1 - Calbiochem
产品型号：233630
Cryptotanshinone is shown to inhibit the constitutive STAT3 Tyr⁷⁰⁵ phosphorylation in DU145 prostate cancer cells independent of the IL-6/JAK/STAT3 signaling pathway.
merck millipore,默克密理博,233630,Cryptotanshinone - CAS 35825-57-1 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₉H₂₀O₃ 35825-57-1 描述 概述 Cryptotanshinone, a cell-permeable diterpene quinone and naturally occurring herbal constituent of Salvia miltiorrhiza Bunge (Danshen), is shown to inhibit the constitutive STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells (>90% inhibition in 1 h at 7 µM) independent of the IL-6/JAK/STAT3 signaling pathway, resulting in a blockage of STAT3 dimerization, nuclear translocation, and STAT3-dependent transcription activity (by ~80% in 24 h at 7 µM). Cryptotanshinone is also reported to deplete cellular ATP level (by 75% in 12 h at 20 µM in C2C12 myotubes), resulting in an indirect activation of cellular AMPK pathways and an enhancement of insulin-stimulated cellular glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes (by ~1.3- and 1.9-fold, respectively). Cryptotanshinone is demonstrated to be an orally active hypoglycemic agent in ob/ob mice, db/db mice, and ZDF rats in vivo (600 mg/kg/day). 产品目录编号 233630 品牌系列 Calbiochem®
同义词 AMPK Signaling Activator VIII 参考 参考 Shin, D.S., et al. 2009. Cancer Res. 69, 193.
Kim, E.J., et al. 2007. Mol. Pharmacol. 72, 62.产品信息 CAS号 35825-57-1 形式 Orange solid Hill配方 C₁₉H₂₀O₃ 化学配方 C₁₉H₂₀O₃ Molar Mass 296.4 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO or EtOH 安全信息 S相 S: 22-24/25-36/37-45
Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing and gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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