merck millipore,默克密理博,MAB5680,Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, M	WB, FC, ICC, IHC	M	Purified	Monoclonal Antibody

描述
产品目录编号	MAB5680
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody
Alternate Names	MOG
背景信息	Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The amino acid sequence of MOG is highly conserved among animal species (>90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive function within the CNS . Consistent with MOG's possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ.

应用
应用	Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody is an antibody against Myelin Oligodendrocyte Glycoprotein (MOG) for use in FC, IC, IH & WB.
主要应用	Western Blotting Flow Cytometry Immunocytochemistry Immunohistochemistry

生物信息
免疫原品种	Rat cerebellar glycoproteins
表位	The antibody binds to a discontinuous epitope present on the extracellular immunoglobulin V-like domain of MOG.
克隆	8-18C5
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	Membane associated region of MOG [Myelin oligodendrocyte glycoprotein].
同种型	IgG1
品种反应性	RatMouse
Species Reactivity Note	May cross react with human and bovine based on sequence similarity.
抗体类型	Monoclonal Antibody
Entrez基因编号	M99485.1
纯化方法	Purified immunoglobulin
UniProt编号	Q63345
UniProt汇总	FUNCTION: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. SUBUNIT: May form homodimers. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes. DEVELOPMENTAL STAGE: A peak of expression has been observed between postnatal days 15 and 25, coinciding with the period of active myelination. SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. CAUTION: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG).

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MAB5680,Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody

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