merck millipore,默克密理愽
  • merck millipore,默克密理博,14-585,MAPKAP Kinase 3 Protein, active, 10 µg

  • merck millipore,默克密理博,14-585,MAPKAP Kinase 3 Protein, active, 10 µg

    产品名称：MAPKAP Kinase 3 Protein, active, 10 µg
    产品型号：14-585
    Active, N-terminal GST-tagged, recombinant, human MAPKAP Kinase 3, amino acids 2-end. Activated using SAPK2a (Catalog #14-587). For use in Kinase Assays.

    merck millipore,默克密理博,14-585,MAPKAP Kinase 3 Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-585,MAPKAP Kinase 3 Protein, active, 10 µg

    描述
    产品目录编号 14-585
    品牌系列 Upstate
    商名
    • Upstate
    描述 MAPKAP Kinase 3 Protein, active, 10 µg
    概述 expressed in E. coli; activated using SAPK2a (Catalog #14-587)
    应用
    应用 Active, N-terminal GST-tagged, recombinant, human MAPKAP Kinase 3, amino acids 2-end. Activated using SAPK2a (Catalog #14-587). For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 N-terminal GST-tagged, recombinant, human MAPKAP Kinase 3, amino acids 2-end
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_004635.3
    Entrez基因汇总 This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.
    基因符号
    • 3pK
    • MAPKAPK3
    • MAPKAP
    • MAPKAP3
    • 3PK
    • MAPKAPK-3
    蛋白靶 MAPKAP-K3
    纯化方法 Glutathione agarose affinity chromatography
    靶子系列 CAMK
    UniProt编号
    • Q16644
    UniProt汇总 FUNCTION: SwissProt: Q16644 # Modulator of polycomb-mediated repression, which can be activated either by ERK, p38 and JNK. Substrate of CSBP. In vitro, phosphorylates HSPB1, BMI1/PCGF4 and TCF3.
    SIZE: 382 amino acids; 42987 Da
    SUBUNIT: Interacts with TCF3 and with polycomb proteins, such as PCH2 and BMI1/PCGF4.
    SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly located in the nucleus, when activated it translocates to the cytoplasm.
    TISSUE SPECIFICITY: Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain.
    SIMILARITY: SwissProt: Q16644 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of MAPKAP Kinase 2 Substrate Peptide (Catalog #12-240)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 10 µg
    包装 Also available in 250 µg size --call for pricing and availability and reference catalog number 14-585M when ordering the 250 µg size.

    merck millipore,默克密理博,14-585,MAPKAP Kinase 3 Protein, active, 10 µg

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