merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB5550,Anti-TorsinA Antibody

  • merck millipore,默克密理博,MAB5550,Anti-TorsinA Antibody

    产品名称：Anti-TorsinA Antibody
    产品型号：MAB5550
    This Anti-TorsinA Antibody is validated for use in IP, WB, IC for the detection of TorsinA.

    merck millipore,默克密理博,MAB5550,Anti-TorsinA Antibody

  • 产品介绍
  • merck millipore,默克密理博,MAB5550,Anti-TorsinA Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, WBMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB5550
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-TorsinA Antibody
    背景信息 TorsinA can regulate the cellular trafficking of the dopamine transporter, as well as other polytopic membrane-bound proteins, including G protein-coupled receptors, transporters, and ion channels. TorsinA is found in the dopamine neurons that are lost in PD, and is a component of Lewy bodies. in addition, a genetic defect in TorsinA underlies Torsion dystonia, a disease characterized by painful muscle contractions that result in uncontrollable distortions.
    产品信息
    格式 Ascites
    控制
    • Positive Control: Human brain lysate, NGF treated PC12 cells.
    演示 Liquid. Contaings no preservative
    应用
    应用 This Anti-TorsinA Antibody is validated for use in IP, WB, IC for the detection of TorsinA.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    生物信息
    免疫原品种 Maltose binding protein fusion protein from human torsinA.
    宿主 Mouse
    特异性 TorsinA
    同种型 IgG1
    品种反应性 RatHumanMouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000113.2
    Entrez基因汇总 The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1.
    基因符号
    • DQ2
    • TOR1A
    • DQ1
    • DYT1
    • TOR1B
    纯化方法 Ascites
    UniProt编号
    • O14656
    UniProt汇总 FUNCTION: SwissProt: O14656 # May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.
    SIZE: 332 amino acids; 37809 Da
    SUBUNIT: Interacts with TOR1AIP1 and TOR1AIP2.
    SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Nucleus membrane. Note=Mainly located in the lumen of the endoplasmic reticulum. Also found associated with the nuclear envelope. The Glu-303 del variant is lumenally-oriented in discrete large spheroid intracellular structures rather than in the endoplasmic reticulum.
    TISSUE SPECIFICITY: Widely expressed. Highest levels in kidney and liver. Not detected in spleen. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also high expression in the spinal cord.
    DISEASE: SwissProt: O14656 # Defects in TOR1A are the cause of torsion dystonia 1 (DYT1) [MIM:128100]; also known as primary or idiopathic dystonia. This autosomal dominant disorder is the most common and severe type of dystonia manifesting itself as sustained muscle contractions inducing twisting and repetitive movements and/or abnormal posture. Symptoms usually begin in the arms or legs at a mean age of 12 years and progress to other body parts within 5 years.
    SIMILARITY: SwissProt: O14656 ## Belongs to the clpA/clpB family. Torsin subfamily.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB5550,Anti-TorsinA Antibody

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