merck millipore,默克密理博,MAB5276,Anti-Endorphin β Antibody, clone 3-E7

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merck millipore,默克密理博,MAB5276,Anti-Endorphin β Antibody, clone 3-E7
产品名称：Anti-Endorphin β Antibody, clone 3-E7
产品型号：MAB5276
This Anti-Endorphin Antibody, β, clone 3-E7 is validated for use in ELISA, IH for the detection of Endorphin.

merck millipore,默克密理博,MAB5276,Anti-Endorphin β Antibody, clone 3-E7

产品介绍

merck millipore,默克密理博,MAB5276,Anti-Endorphin β Antibody, clone 3-E7

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Po, H	IHC, ELISA	M	Purified	Monoclonal Antibody

描述
产品目录编号	MAB5276
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Endorphin β Antibody, clone 3-E7

产品信息
格式	Purified
演示	Purified immunoglobulin. Liquid in 0.02M Phosphate buffer with 0.25M NaCl and 0.1% sodium azide.

应用
应用	This Anti-Endorphin Antibody, β, clone 3-E7 is validated for use in ELISA, IH for the detection of Endorphin.
主要应用	Immunohistochemistry ELISA
应用说明	ELISA Immunohistochemistry Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	Synthetic human beta-endorphin coupled with poly-lysine or thyroglobulin (Gramsch et al., 1983; Meo et al., 1983) (H-Tyr-Gly-Gly-Phe sequence).
克隆	3-E7
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	The antibody reacts with the amino terminal H-Tyr-Gly-Gly-Phe sequence of human O-endorphin. Therefore, a high cross-reactivity with homologues of identical sequence, such as [Met]-enkephalin and [Leu]-enkephalin and a number of opioid peptides, occurs; the antibody also reacts with swine and camel O-endorphin. However, the antibody does not recognize human beta-lipotropin and N-acetyl-beta-endorphin (Gramsch et al., 1983; Meo et al., 1983; Herz et al., 1982).
同种型	IgG2a
品种反应性	PigHuman
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_001035256.1 NM_000939.2
Entrez基因汇总	This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
基因符号	gamma-MSH POMC pro-ACTH-endorphin adrenocorticotropin beta-LPH POC gamma-LPH LPH beta-endorphin corticotropin ACTH alpha-MSH beta-MSH pro-opiomelanocortin proopiomelanocortin Pro-opiomelanocortin NPP corticotropin-lipotrophin MSH met-enkephalin CLIP
UniProt编号	P01189
UniProt汇总	FUNCTION: SwissProt: P01189 # Beta-endorphin and Met-enkephalin are endogenous opiates. SIZE: 267 amino acids; 29424 Da TISSUE SPECIFICITY: ACTH and MSH are produced by the pituitary gland. PTM: Specific enzymatic cleavages at paired basic residues yield the different active peptides. & O-glycosylated; reducing sugar is probably N- acetylgalactosamine. DISEASE: SwissProt: P01189 # Defects in POMC may be associated with susceptibility to obesity [MIM:601665]. & Defects in POMC are the cause of pro-opiomelanocortinin deficiency [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair. SIMILARITY: SwissProt: P01189 ## Belongs to the POMC family.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain at 2-8°C in undiluted aliquots for up to 6 months.

包装信息
数量	40 µg

merck millipore,默克密理博,MAB5276,Anti-Endorphin β Antibody, clone 3-E7

上一件merck millipore产品：merck millipore,默克密理博,09-241,Anti-phospho JAK-2 (Tyr570) Antibody
下一件merck millipore产品：merck millipore,默克密理博,AB6010,Anti-MMP-12 Antibody, NT (active)

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