- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, ICC, IHC M Purified Monoclonal Antibody 描述 产品目录编号 MAB5220 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-NMDAR2B Antibody, clone 13A11 Alternate Names - NR2B
产品信息 格式 Purified 演示 Affinity purified immunoglobulin. Liquid in PBS. Contains no preservative. 应用 应用 Anti-NMDAR2B Antibody, clone 13A11 is an antibody against NMDAR2B for use in IC, IH & WB. 主要应用 - Western Blotting
- Immunocytochemistry
- Immunohistochemistry
应用说明 Immunohistochemistry (light and EM) on 4% paraformaldehyde & 0.125% glutaraldehyde fixed tissue: 2.5-5 μg/mL.
Immunocytochemistry: 2.5-5.0 μg/mL
Western blot: 1-5 μg/mL Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Amino acid region 1033-1161 from human NMDAR2B produced as a GST fusion protein. 克隆 13A11 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 NMDAR2B 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000834.2
Entrez基因汇总 N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. 基因符号 - hNR3
- GRIN2B
- MGC142180
- Glutamate
- NMDAR2B
- NR3
- NR2B
- MGC142178
UniProt编号 - Q13224
UniProt汇总 FUNCTION: SwissProt: Q13224 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
SIZE: 1484 amino acids; 166367 Da
SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
SIMILARITY: SwissProt: Q13224 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,06-1433,Anti-phospho-FGFR-1 (Tyr653/Tyr654) Antibody
下一件merck millipore产品：merck millipore,默克密理博,ST1714,Anti-PAPPA Mouse mAb (1G3)
相关产品
merck millipore,默克密理博,MAB3584,Anti-Heterochromatin Protein-1 α Antibody, clone 2HP-1H5
merck millipore,默克密理博,17-10260,ChIPAb+™ N-CoR Antibody
merck millipore,默克密理博,14-346M,CHK1 Protein, active, 250 µg
merck millipore,默克密理博,06-1433,Anti-phospho-FGFR-1 (Tyr653/Tyr654) Antibody
merck millipore,默克密理博,ST1714,Anti-PAPPA Mouse mAb (1G3)
merck millipore,默克密理博,17-10264,ChIPAb+™ JHDM1B Antibody
merck millipore,默克密理博,FCMAB111F,Milli-Mark™ Anti-HESCA-1-FITC Antibody, clone 051007-4A5
merck millipore,默克密理博,234415,C5a Receptor Antagonist, W-54011 - CAS 405098-33-1 - Calbiochem
merck millipore,默克密理博,FCMAB199P,Milli-Mark™ Anti-CD56-PE Antibody, clone C5.9