merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB4433,Anti-Podocalyxin-like protein I Antibody, clone 85

  • merck millipore,默克密理博,MAB4433,Anti-Podocalyxin-like protein I Antibody, clone 85

    产品名称：Anti-Podocalyxin-like protein I Antibody, clone 85
    产品型号：MAB4433
    Detect Podocalyxin-like protein I using this Anti-Podocalyxin-like protein I Antibody, clone 85 validated for use in IC, FC & WB.

    merck millipore,默克密理博,MAB4433,Anti-Podocalyxin-like protein I Antibody, clone 85

  • 产品介绍
  • merck millipore,默克密理博,MAB4433,Anti-Podocalyxin-like protein I Antibody, clone 85

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ICC, FCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB4433
    描述 Anti-Podocalyxin-like protein I Antibody, clone 85
    Alternate Names
    • podocalyxin-like
    背景信息 Podocalyxin-like protein 1(Podocalyxin) is a transmembrane protein known to be heavily sialyated and sulfated that is localized on the apical surface of podocytes and on vascular endothelia. Originally, the protein was characterized as a marker for vasculature and podocytes, but expression has since been observed in platelets, hematopoietic precursor cells and mesothelial cells from the coelmic cavity lining. Studies have outlined two distinct and seemingly adverse roles for this protein; it acts as an anti-adhesion molecule in renal glomerulae podocytes, but functions as an adhesion molecule within vasculature on high endothelial venules. Podocalyxin expression has been implicated in the development of aggressive cancers, beta catenin signaling, angiogenisis, and both myeloid and acute lymphoblastic leukemias.
    产品信息
    格式 Purified
    控制
    • Human embryonic stem cells
    演示 Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
    应用
    应用 Detect Podocalyxin-like protein I using this Anti-Podocalyxin-like protein I Antibody, clone 85 validated for use in IC, FC & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    • Flow Cytometry
    应用说明 Western Blot Analysis: A previous lot was used by an independent laboratory in WB (Choo, A., et al., 2008).

    Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC (Choo, A., et al., 2008).
    生物信息
    免疫原品种 Human embryonic stem cells.
    表位 Extracellular Domain
    克隆 clone 85
    宿主 Mouse
    特异性 This antibody recognizes the extracellular domain of Podocalyxin-like protein 1.
    Unlike it's counterpart (clone mAb 84, MAB4414), this antibody is not cytotoxic.
    同种型 IgMκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001018121
    Entrez基因汇总 This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq].
    基因符号
    • PCLP1
    • PCLP
    • Gp200
    • PC
    纯化方法 Ion exchange purification column
    UniProt编号
    • O00592
    UniProt汇总 FUNCTION: Functions as an antiadhesin that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion.

    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Potential.

    TISSUE SPECIFICITY: Glomerular epithelium cell (podocyte).

    PTM: Glycosylated; contains sialic acid.

    SEQUENCE SIMILARITIES: Belongs to the podocalyxin family.
    产品使用声明
    质量保证 Evaluated by Immunocytochemistry in human embryonic stem cells.

    Immunocytochemistry Analysis: A 1:50 dilution of this antibody detected Podocalyxin-like protein I in human embryonic stem cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,MAB4433,Anti-Podocalyxin-like protein I Antibody, clone 85

上一件merck millipore产品：merck millipore,默克密理博,SCGPT05RE,Steritop-GP，0.22 µm，改良聚醚砜，500 mL 45 mm，射线灭菌
下一件merck millipore产品：merck millipore,默克密理博,400051,Hygromycin B, Streptomyces sp. - CAS 31282-04-9 - Calbiochem


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