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merck millipore,默克密理博,400051,Hygromycin B, Streptomyces sp. - CAS 31282-04-9 - Calbiochem
产品名称：Hygromycin B, Streptomyces sp. - CAS 31282-04-9 - Calbiochem
产品型号：400051
Unique aminoglycoside antibiotic that inhibits the growth of prokaryotic (bacteria) and eukaryotic microorganisms (yeasts) and mammalian cells.
merck millipore,默克密理博,400051,Hygromycin B, Streptomyces sp. - CAS 31282-04-9 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₀H₃₇N₃O₁₃ 31282-04-9 描述 概述 Unique aminoglycoside antibiotic that inhibits the growth of prokaryotic (bacteria) and eukaryotic microorganisms (yeasts) and mammalian cells. Inhibits protein synthesis at the translocation step on the 70S ribosome and causes misreading of the mRNA. Hph, a gene from E. coli, encodes resistance to hygromycin B and can be isolated and cloned by recombinant DNA techniques. This hygromycin B-resistance gene is particularly useful for identification or selection of recombinant clones in a variety of cell types. Hygromycin B penetrates cells that have been permeabilized by virus infection and can act as an effective antiviral agent. Bioassay: 350-450 units/mg Hygromycin B. 106 units is equivalent to ~900 mg. Supplied with a directional insert. Note: 1 KU = 1000 units; 1 MU = 1,000,000 units. 产品目录编号 400051 品牌系列 Calbiochem®
参考 参考 Dean, N. 1995. Proc. Natl. Acad. Sci. USA 92, 1287.
Hamada, W., et al. 1994. Curr. Genetics 26, 251.
Hubbard, S. C., et al. 1994. J. Biol. Chem. 269, 3717.
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Buchschacher, G.L., Jr., and Panganiban, A.T. 1992. J. Virol. 66, 2731.
Gaken, J., et al. 1992. Biotechniques 13, 32.
Lama, J., and Carrasco, L. 1992. J. Biol. Chem. 267, 15932.
Ma, H., et al. 1992. Gene 117, 161.
MacIntyre, G., et al. 1992. Adv. Exp. Med. Biol. 276, 67.
Norman, J.A., et al. 1992. Mol. Pharmacol. 41, 53.
Bilang, R., et al. 1991. Gene 100, 247.
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Lee, M.G-S., and Van der Ploeg, L. 1991. Gene 105, 255.
Leslie, J.F., and Dickman, M.B. 1991. Applied Environ. Microbiol. 57, 1423.
MacIntyre, G., et al. 1991. Antimicrob. Agents Chemother. 35, 2125.
Zhou, J., et al. 1991. Gene 107, 307.
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Giordano, T.J., and McAllister, W.T. 1990. Gene 88, 285.
Salauze, D., et al. 1990. Antimicrob. Agents Chemother. 24, 1915.
Carrasco, L., et al. 1989. Pharmacol. Ther. 9, 311.
Crespi, C.L., et al. 1989. Carcinogenesis 10, 295.
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Egelhoff, T.T., et al. 1989. Mol. Cell. Biol. 9, 1965.
Kronstad, J.W., et al. 1989. Gene 79, 97.
Perlin, D.S., et al. 1988. J. Biol. Chem. 263, 118.
Cullen, D., et al. 1987. Gene 57, 21.
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Malpartida, F., et al. 1983. Biochem. Biophys. Res. Commun. 117, 6.
Rao, S.N., et al. 1983. Antimicrob. Agents Chemother. 24, 689.产品信息 CAS号 31282-04-9 形式 Dark brown liquid Hill配方 C₂₀H₃₇N₃O₁₃ 化学配方 C₂₀H₃₇N₃O₁₃ Molar Mass 527.5 结构配方图像 生物信息 生物活性 The activity of Hygromycin B is measured in a zonal inhibition assay using Bacillus subtilis. The activity is measured relative to a reference standard. 主靶 growth of prokaryotic (bacteria) and eukaryotic microorganisms (yeasts) and mammalian cells 副靶 protein synthesis at the translocation step on the 70S ribosome and causes misreading of the mRNA 纯度 >85% by HPLC GHS安全信息 RTECS WK2130000 安全信息 R相 R: 26/27/28-37/38-41
Very toxic by inhalation, in contact with skin and if swallowed.
Irritating to respiratory system and skin.
Risk of serious damage to eyes.S相 S: 23-26-36/37/39-45
Do not breathe fumes.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Ambient Temperature Only
毒性 Highly Toxic & Carcinogenic / Teratogenic
有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存 +2°C to +8°C
无需冷冻 No
特殊指南 Aqueous stock solutions should be kept at concentrations of ≥50 mg/ml and can be stored at either 4°C or -20°C. Aqueous stock solutions (≥50 mg/ml) are stable for up to 6 months at 4°C or -20°C. Working solutions (< 2 mg/ml) are stable for up to 1 month at 4°C.
Note: This product is highly toxic. Read enclosed MSDS before handling.
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