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描述 概述 Synthesized from isoamyl nitrite and hydrogen peroxide. Peroxynitrite (ONOO–) is a cell-permeable strong biological oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine. Has been implicated in a variety of pathophysiological conditions including acute respiratory distress syndrome (ARDS), arthritis, atherosclerosis, inflammatory bowel disease, ischemia-reperfusion, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity, and septic shock. Note: 1 set = 2 x 1 ml. 产品目录编号 516620 品牌系列 Calbiochem®
参考 参考 Marla, S.S., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 14243.
Sakuma, S., et al. 1997. Biochem. Biophys. Res. Commun. 230, 476.
Lymar, S.V., et al. 1996. Biochemistry 35, 7855.
Uppu, R.M., and Pryor, W.A. 1996. Methods Enzymol. 269, 322.
Ischiropoulos, H., and al-Medhi, A.B. 1995. FEBS Lett. 364, 279.产品信息 具有ATP竞争性 N 形式 Yellow liquid 配方 Supplied in 4.7% NaOH at 160-200 mM. Molar Mass 85.0 可逆 N 生物信息 主靶 Oxidizing agent that reacts with DNA, membrane phospholipids, sulfhydryl groups, and tyrosine 理化信息 细胞可渗透 Y 安全信息 R相 R: 8-20/22-34
Contact with combustible material may cause fire.
Harmful by inhalation and if swallowed.
Causes burns.S相 S: 3-28-36/37/39-45
Keep in a cool place.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Dry Ice Only
毒性 Oxidizer
有害材料注意事项: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存 ≤ -70°C
避光 Protect from light
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Protect from heat, light, metal ions, and air. Peroxynitrite is unstable; thaw rapidly, dispense into aliquots, purge tubes with an inert gas, and freeze -70°C. Activity decreases ~2% /day at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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