merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB4419,Anti-OCT-4 [POU5F1] Antibody, clone 7F9.2

  • merck millipore,默克密理博,MAB4419,Anti-OCT-4 [POU5F1] Antibody, clone 7F9.2

    产品名称：Anti-OCT-4 [POU5F1] Antibody, clone 7F9.2
    产品型号：MAB4419
    This Anti-OCT-4 [POU5F1] Antibody, clone 7F9.2 is validated for use in IC, FC, WB for the detection of OCT-4 [POU5F1].

    merck millipore,默克密理博,MAB4419,Anti-OCT-4 [POU5F1] Antibody, clone 7F9.2

  • 产品介绍
  • merck millipore,默克密理博,MAB4419,Anti-OCT-4 [POU5F1] Antibody, clone 7F9.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWB, ICC, FCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB4419
    Replaces MAB4305
    描述 Anti-OCT-4 [POU5F1] Antibody, clone 7F9.2
    Alternate Names
    • octamer-binding transcription factor-3
    • Octamer-binding transcription factor 3
    • POU class 5 homeobox 1
    • POU domain class 5, transcription factor 1
    • POU-type homeodomain-containing DNA-binding protein
    背景信息 Octamer-4 (Oct-4), a member of the POU family of transcription factors, has been demonstrated to be vital for the formation of self-renewing pluripotent stem cells. During embryogenesis, expression of Oct-4 is limited to pluripotent cells of the inner cell mass (ICM) that contribute to the formation of all fetal cell types. This relationship between Oct-4 and pluripotency has seen this transcription factor emerge as a marker of pluripotent stem cells. Undifferentiated human and murine pluripotent Embryonic Stem (ES) and Embryonic Carcinoma (EC) cells express Oct-4. Additionally, murine Embryonic Germ (EG) cells are also known to express Oct-4. Following stem cell differentiation, the level of Oct-4 expression decreases. Oct-4 expression by human EG cells is not known.
    产品信息
    格式 Purified
    演示 Purified mouse monoclonal IgG1κ in a buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl, and 0.05% NaN3.
    应用
    应用 This Anti-OCT-4 [POU5F1] Antibody, clone 7F9.2 is validated for use in IC, FC, WB for the detection of OCT-4 [POU5F1].
    主要应用
    • Western Blotting
    • Immunocytochemistry
    • Flow Cytometry
    应用说明 Western Blotting: Recommended working dilution is 1 - 2 µg/mL.

    Flow Cytometry: Recommended working dilution is 2 µg/mL.

    Immunocytochemistry: Recommended working dilution is 1:100 – 1: 200.
    生物信息
    免疫原品种 Recombinant human Oct-4 protein, a.a. 1-145.
    克隆 7F9.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody reacts with the intracellular protein, Oct-4 and detects the Oct-4A isoform.
    同种型 IgG1κ
    品种反应性 MouseHuman
    Species Reactivity Note Reacts with both human and mouse Oct-4; however, reactivity to other species has not been determined.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_976034
    基因符号
    • Oct-4
    • OCT3
    • OCT4
    • OTF3
    • OTF4
    • Oct-3
    纯化方法 Protein G sepharose column
    UniProt编号
    • P20263
    UniProt汇总 FUNCTION: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
    SUBUNIT STRUCTURE:Interacts with UBE2I.
    SUBCELLULAR LOCATION: Nucleus. Note= Expressed in a diffuse and slightly punctuate pattern.
    TISSUE SPECIFICTY: Expressed the totipotent and pluripotent stem cells of the pregastrulation embryo. Also expressed in primordial germ cells and in the female germ line. Absent from adult tissues.
    DEVELOPMENTAL STAGE: Down-regulated during differentiation to endoderm and mesoderm. Ref.1
    INDUCTION: Repressed by retinoic acid (RA).
    PTM: Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression.
    SEQUENCE SIMILARITIES: Belongs to the POU transcription factor family. Class-5 subfamily.
    Contains 1 homeobox DNA-binding domain.
    Contains 1 POU-specific domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB4419,Anti-OCT-4 [POU5F1] Antibody, clone 7F9.2

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