merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB427,Anti-Dihydropyridine-sensitive Calcium Channel α 1 Subunit Antibody, clone 1a

  • merck millipore,默克密理博,MAB427,Anti-Dihydropyridine-sensitive Calcium Channel α 1 Subunit Antibody, clone 1a

    产品名称：Anti-Dihydropyridine-sensitive Calcium Channel α 1 Subunit Antibody, clone 1a
    产品型号：MAB427
    Anti-Dihydropyridine-sensitive Calcium Channel α 1 Subunit Antibody, clone 1a is an antibody against Dihydropyridine-sensitive Calcium Channel α 1 Subunit for use in FC, IP & WB.

    merck millipore,默克密理博,MAB427,Anti-Dihydropyridine-sensitive Calcium Channel α 1 Subunit Antibody, clone 1a

  • 产品介绍
  • merck millipore,默克密理博,MAB427,Anti-Dihydropyridine-sensitive Calcium Channel α 1 Subunit Antibody, clone 1a

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Rb, H, M, RWB, FCMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB427
    Replaces 06-422
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Dihydropyridine-sensitive Calcium Channel α 1 Subunit Antibody, clone 1a
    产品信息
    格式 Ascites
    演示 Ascites.
    应用
    应用 Anti-Dihydropyridine-sensitive Calcium Channel α 1 Subunit Antibody, clone 1a is an antibody against Dihydropyridine-sensitive Calcium Channel α 1 Subunit for use in FC, IP & WB.
    主要应用
    • Western Blotting
    • Flow Cytometry
    应用说明 Western blot, immunoprecipitation and FACS.

    Optimal working dilutions must be determined by end user.
    生物信息
    克隆 mAB 1a
    宿主 Mouse
    特异性 Dihydropyridine calcium channel, a1 subunit as determined by Western blot (~210 kDa), immunoprecipitation and functional test. Membrane preparations are recommended. The mouse muscle cell line, BC3H1 functions as a good positive control cell line. Reactive with L-type calcium channel alpha1 subunit. Specific for small cell carcinoma and neuroblastoma by FACS analysis. No interaction with squamous cell carcinoma or with cardiac calcium chanel isoforms.
    同种型 IgG1
    品种反应性 RabbitHumanMouseRat
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000069.2
    Entrez基因汇总 This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility.
    基因符号
    • HypoPP
    • CACNA1S
    • CACH1
    • CCHL1A3
    • hypoPP
    • MHS5
    • CACNL1A3
    • Cav1.1
    • HOKPP
    • CACN1
    UniProt编号
    • Q13698
    UniProt汇总 FUNCTION: SwissProt: Q13698 # Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the high-voltage activated (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.
    SIZE: 1873 amino acids; 212164 Da
    SUBUNIT: Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. An additional gamma subunit is present only in skeletal muscle L-type channel.
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Skeletal muscle specific.
    DOMAIN: SwissProt: Q13698 Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. & The loop between repeats II and III interacts with the ryanodine receptor, and is therefore important for calcium release from the endoplasmic reticulum necessary for muscle contraction.
    PTM: Phosphorylation by PKA activates the calcium channel (By similarity).
    DISEASE: SwissProt: Q13698 # Defects in CACNA1S are a cause of hypokalemic periodic paralysis (HYPOKPP) [MIM:170400]; also designated HOKPP. HYPOKPP is an autosomal dominant skeletal muscle disorder manifested by episodic weakness associated with low serum potassium. Muscle weakness could be due to altered excitation-contraction coupling in HYPOKPP patients. & Defects in CACNA1S are the cause of malignant hyperthermia susceptibility 5 (MHS5) [MIM:601887]; an autosomal dominant disorder that is potentially lethal in susceptible individuals on exposure to commonly used inhalational anesthetics and depolarizing muscle relaxants.
    SIMILARITY: Belongs to the calcium channel alpha-1 subunit family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB427,Anti-Dihydropyridine-sensitive Calcium Channel α 1 Subunit Antibody, clone 1a

上一件merck millipore产品：merck millipore,默克密理博,557370,Rottlerin - CAS 82-08-6 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,07-385,Anti-phospho-PKD2 (Ser876) Antibody


相关产品

merck millipore,默克密理博,SF-733,APC; Human, Cyanine 3, RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-733,APC; Human, Cyanine 3, RNA Detection Probe,SmartFlare

merck millipore,默克密理博,14-435M,DYRK1A Protein, active, 250 µg merck millipore,默克密理博,14-435M,DYRK1A Protein, active, 250 µg

merck millipore,默克密理博,FCMAB104A4,Anti-phospho H3 (Ser10) Antibody, clone 3H10 Alexa Fluor 488 merck millipore,默克密理博,FCMAB104A4,Anti-phospho H3 (Ser10) Antibody, clone 3H10 Alexa Fluor 488

merck millipore,默克密理博,AM41,Suicide Track™ DNA Ladder Isolation Kit merck millipore,默克密理博,AM41,Suicide Track™ DNA Ladder Isolation Kit

merck millipore,默克密理博,557370,Rottlerin - CAS 82-08-6 - Calbiochem merck millipore,默克密理博,557370,Rottlerin - CAS 82-08-6 - Calbiochem

merck millipore,默克密理博,07-385,Anti-phospho-PKD2 (Ser876) Antibody merck millipore,默克密理博,07-385,Anti-phospho-PKD2 (Ser876) Antibody

merck millipore,默克密理博,20-169,Protein Phosphatase Dilution Buffer merck millipore,默克密理博,20-169,Protein Phosphatase Dilution Buffer

merck millipore,默克密理博,69911,pET-30c(+) DNA - Novagen merck millipore,默克密理博,69911,pET-30c(+) DNA - Novagen

merck millipore,默克密理博,ABE547,Anti-ALKBH5 Antibody merck millipore,默克密理博,ABE547,Anti-ALKBH5 Antibody

merck millipore,默克密理博,124019,Akt Inhibitor IX, API-59CJ-OMe - CAS 98510-80-6 - Calbiochem merck millipore,默克密理博,124019,Akt Inhibitor IX, API-59CJ-OMe - CAS 98510-80-6 - Calbiochem


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部