merck millipore,默克密理愽
  • merck millipore,默克密理博,557370,Rottlerin - CAS 82-08-6 - Calbiochem

  • merck millipore,默克密理博,557370,Rottlerin - CAS 82-08-6 - Calbiochem

    产品名称：Rottlerin - CAS 82-08-6 - Calbiochem
    产品型号：557370
    A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC₅₀ = 3-6 µM) and PKCθ.

    merck millipore,默克密理博,557370,Rottlerin - CAS 82-08-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,557370,Rottlerin - CAS 82-08-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₃₀H₂₈O₈82-08-6
    描述
    概述 A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC50 = 3-6 µM) and PKCθ. Inhibits the PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCζ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM).
    产品目录编号 557370
    品牌系列 Calbiochem®
    同义词 Mallotoxin
    参考
    参考 Villalba, M., et al. 1999. J. Immunol. 163, 5813.
    Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93.
    Gschwendt, M., et al. 1994. FEBS Lett. 338, 85.
    Gschwendt, M., et al. 1984. Cancer Lett. 25, 177.
    产品信息
    CAS号 82-08-6
    具有ATP竞争性 N
    形式 Orange solid
    Hill配方 C₃₀H₂₈O₈
    化学配方 C₃₀H₂₈O₈
    Molar Mass 516.5
    可逆 Y
    结构配方图像
    生物信息
    主靶 PKCδ
    主靶IC50 3-6 µM against PKCδ; 5.3 µM against CaM kinase III
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    GHS安全信息
    RTECS AM6913800
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,557370,Rottlerin - CAS 82-08-6 - Calbiochem

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