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merck millipore,默克密理博,MAB4023,Anti-c-erbB-3 Antibody, cytoplasmic domain, clone RTJ2
产品名称：Anti-c-erbB-3 Antibody, cytoplasmic domain, clone RTJ2
产品型号：MAB4023
Detect c-erbB-3 using this Anti-c-erbB-3 Antibody, cytoplasmic domain, clone RTJ2 validated for use in ELISA, IH, IP & WB.
merck millipore,默克密理博,MAB4023,Anti-c-erbB-3 Antibody, cytoplasmic domain, clone RTJ2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, ELISA, IHC M Purified Monoclonal Antibody 描述 产品目录编号 MAB4023 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-c-erbB-3 Antibody, cytoplasmic domain, clone RTJ2 Alternate Names - HER-3
产品信息 格式 Purified 演示 Liquid in PBS, containing azide as a preservative. 应用 应用 Detect c-erbB-3 using this Anti-c-erbB-3 Antibody, cytoplasmic domain, clone RTJ2 validated for use in ELISA, IH, IP & WB. 主要应用 - Western Blotting
- ELISA
- Immunohistochemistry
应用说明 Western blot
ELISA
Immunoprecipitation
Immunohistochemistry
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide corresponding to a site on the cytoplasmic domain of the human c-erbB-3 oncoprotein 表位 cytoplasmic domain 克隆 RTJ2 宿主 Mouse 特异性 Reactive with human c-erB-3. In normal tissues, c-erB-3 is found in non-dividing differentiated epithelial cells, neurons, and hepatocytes. In abnormal tissues, c-erB-3 is found in 80% of GI tract tumors and 20% of breast cancers. 同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001982.2
- NM_001005915.1
Entrez基因汇总 This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. 基因符号 - EC 2.7.10.1
- ERBB3
- c-erbB-3
- LCCS2
- c-erbB3
- p85-sErbB3
- p45-sErbB3
- ErbB-3
- erbB3-S
- erbB-3
- MGC88033
- HER3
- p180-ErbB3
- MDA-BF-1
UniProt编号 - P21860
UniProt汇总 FUNCTION: SwissProt: P21860 # Binds and is activated by neuregulins and NTAK.
SIZE: 1342 amino acids; 148098 Da
SUBUNIT: Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5 and PA2G4.
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
TISSUE SPECIFICITY: Epithelial tissues and brain.
DOMAIN: SwissProt: P21860 The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
PTM: Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (By similarity).
DISEASE: SwissProt: P21860 # Overexpressed in a subset of human mammary tumors. & Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. 包装信息 数量 100 µg
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